Table 1.
Effect of 5 Weeks of Ligand Activation of PPARα With GW7647 Initiated in Perinatal Development on Liver Histopathology in Wild-Type (Ppara+/+), Ppara-Null (Ppara–/–), or PPARA Humanized Mice (PPARA)
| 5 Weeks |
Ppara
+/+
|
Ppara
–/–
|
PPARA
|
||||
|---|---|---|---|---|---|---|---|
| Control | GW7647 | Control | GW7647 | Control | GW7647 | ||
| Centrilobular hypertrophy | None | 3/5 | 0/5 | 4/5 | 4/7 | 4/5 | 6/6 |
| Mild | 1/5 | 5/5 | 1/5 | 3/7 | 1/5 | 0/6 | |
| Moderate | 1/5 | 0/5 | 0/5 | 0/7 | 0/5 | 0/6 | |
| Severe | 0/5 | 0/5 | 0/5 | 0/7 | 0/5 | 0/6 | |
| Necrosis | None | 5/5 | 5/5 | 5/5 | 6/7 | 5/5 | 6/6 |
| Present | 0/5 | 0/5 | 0/5 | 1/7 | 0/5 | 0/6 | |
| Inflammation | None | 5/5 | 5/5 | 5/5 | 7/7 | 5/5 | 6/6 |
| Acute | 0/5 | 0/5 | 0/5 | 0/7 | 0/5 | 0/6 | |
| Chronic | 0/5 | 0/5 | 0/5 | 0/7 | 0/5 | 0/6 | |
| Macrovesicular fatty change | None | 5/5 | 5/5 | 5/5 | 7/7 | 5/5 | 0/6 |
| Mild | 0/5 | 0/5 | 0/5 | 0/7 | 0/5 | 0/6 | |
| Moderate | 0/5 | 0/5 | 0/5 | 0/7 | 0/5 | 6/6 | |
| Severe | 0/5 | 0/5 | 0/5 | 0/7 | 0/5 | 0/6 | |