Figure 3.
Bisphenol inhibition of calcium and potassium currents. Whole-cell voltage-clamp recordings of L-type calcium current (ICaL) following acute (5–10 min) exposure to (A) BPA, (B) BPF, or (C) BPS. D, Dose-dependent inhibition of ICaL (mean ± SD). E, Calculated IC50 values are shown. Whole-cell voltage-clamp recordings of hERG current (IKr) following exposure to (F) BPA, (G) BPF, or (H) BPS. I, Dose-dependent inhibition of IKrL (mean ± SD). J, Calculated IC50 values are shown. n = 4 independent cell recordings per study.