Table 2. Plasma concentration values (micromoles) of dysregulated metabolites according to disease severity.
| Metabolites | G1 N = 37 |
G2 N = 41 |
G3 N = 35 |
G4 N = 45 |
Correlation with disease severity (Spearman coefficient (r), p value (p)) |
|---|---|---|---|---|---|
| Kynurenine:Tryptophan | 0.034±0.007 | 0.08 (0.05–0.11) | 0.075 (0.05–0.12) | 0.13 (0.08–0.19) | 0.5, <0.0001 |
| Glutamic acid | 129.0 (104.0–157.0) | 143.0 (109.5–202.0) | 196.0±69.6 | 201.5 (134.5–243.8) | 0.4, <0.0001 |
| Phenylalanine | 61.05 (54.33–68.8) | 76.10 (61.45–91.70) | 83.9 (70.23–102) | 94.15±27.37 | 0.5, <0.0001 |
| Kynurenine | 1.76 (1.62–2.14) | 2.86 (2.22–4.14) | 3.09±1.62 | 4.12 (2.64–5.47) | 0.4, <0.0001 |
| Butyric acid | 0.67±0.24 | 0.75 (0.55–0.94) | 1.02 (0.89–1.28) | 0.89 (0.72–1.17) | 0.4, <0.0001 |
| Pyruvic acid | 101.6±23.2 | 132 (107.5–230.5) | 107.9±25.93 | 108 (82.9–132) | 0.02, 0.8 |
| LysoPC a C26:1 | 0.06 (0.05–0.09) | 0.081±0.03 | 0.09±0.03 | 0.11±0.03 | 0.5, <0.0001 |
| LysoPC a C26:0 | 0.12 (0.091–0.17) | 0.17±0.052 | 0.18±0.059 | 0.20 (0.17–0.24) | 0.4, <0.0001 |
| LysoPC a C28:1 | 0.14±0.043 | 0.14 (0.11–0.19) | 0.13 (0.12–0.20) | 0.19±0.065 | 0.3, <0.0001 |
| LysoPC a C28:0 | 0.16±0.039 | 0.19±0.060 | 0.19±0.067 | 0.23±0.069 | 0.3, <0.0001 |
| PC ae C36:0 | 1.28±0.28 | 1.24±0.28 | 1.37±0.35 | 1.72±0.53 | 0.3, <0.0001 |
| C4 | 0.18 (0.15–0.29) | 0.20 (0.14–0.28) | 0.23 (0.19–0.29) | 0.38 (0.19–0.51) | 0.2, 0.003 |
| C5 | 0.09 (0.07–0.14) | 0.10 (0.08–0.13) | 0.19 (0.13–0.26) | 0.22 (0.15–0.33) | 0.5, <0.0001 |
| C10:2 | 0.089 (0.07–0.10) | 0.10 (0.08–0.13) | 0.16±0.032 | 0.17±0.026 | 0.7, <0.0001 |
| C10:1 | 0.18±0.039 | 0.21 (0.18–0.27) | 0.22 (0.18–0.29) | 0.25 (0.21–0.35) | 0.4, <0.0001 |
| C10 | 0.17 (0.14–0.24) | 0.223±0.095 | 0.26 (0.120–0.35) | 0.29 (0.19–0.38) | 0.4, <0.0001 |
| trans-Hydroxyproline | 11.5 (6.21–17.85) | 6.52 (3.6–10.04) | 4.54 (3.15–7.12) | 4.55±1.73 | -0.4, <0.0001 |
| Aspartic acid | 18.5 (13.7–26.2) | 15 (10.55–19.6) | 12.59±4.37 | 11 (7.57–16.4) | -0.3, <0.0001 |
| Tryptophan | 50.54±12.35 | 39.63±13.58 | 36.98±13.57 | 34.46±15.45 | -0.4, <0.0001 |
| Citric acid | 128.8±29.22 | 112 (84–136.5) | 100.2±29.7 | 81.9±26.09 | -0.5, <0.0001 |
| LysoPC a C14:0 | 4.12±1.62 | 1.78 (1.25–3.111) | 1.98 (1.51–2.34) | 1.83 (1.55–2.44) | -0.4, <0.0001 |
| LysoPC a C16:1 | 3.63 (2.77–4.25) | 2.34 (1.59–3.35) | 2.15±0.84 | 1.98 (1.59–2.57) | -0.3, <0.0001 |
| LysoPC a C18:2 | 25.09 (19.3–30.9) | 15.9 (9.14–22.5) | 12.71 (8.31–17.0) | 11.18 (7.77–13.9) | -0.5, <0.0001 |
| LysoPC a C18:1 | 20.95 (17.5–23.7) | 14.9 (11.0–20.6) | 14.9 (11.5–19.06) | 14.62±4.65 | -0.3, <0.0001 |