Table 1.

Proposed Criteria for Diagnosis of Lupus Podocytopathy

Parameter	Features
Clinical	Diagnosis of SLE by ACR criteria; full nephrotic syndrome (ie, nephrotic-range proteinuria, hypoalbuminemia, and edema)
Light microscopy	Normal glomeruli or FSGS; mesangial proliferation permitted; endocapillary proliferation, necrosis, and/or crescents not permitted
Immunofluorescence microscopy	Deposits absent or confined to mesangium
Electron microscopy	Diffuse and severe foot process effacement (typically >70%); deposits absent or confined to mesangium

Abbreviations: ACR, American College of Rheumatology; FSGS, focal segmental glomerulosclerosis; SLE, systemic lupus erythematosus.

Adapted from Bomback and Markowitz.¹¹