Pediatric and Adult manifestation of the DICER1 syndrome. DICER1
syndrome is a cancer predisposition syndrome, which has an overrepresentation of
numerous tumors including pinoblastomas, pleuropulmonary blastoma (PPB),
pituitary blastomas (PitB), cystic nephroma, Ovarian sex Cord-Stromal Tumors
(OSCST), Sertoli-Leydig Cell Tumors (SLCT), nasal chondromesenchymal hamartoma
(NCMH), cervix embryonal rhabdomyosarcoma (cERMs), multimodular
goiter/differentiated thyroid caner (MNG/DTC) and ciliary body
medulloepithelioma (CBME, adapted from Choong et al. 2012).
(A higher resolution/colour version of this figure is available in
the electronic copy of the article).