Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Crispr targeting exon 25. We designed gRNAs that would target specific sequences in the introns flanking exon 25. This deletion has been shown to be functionally equivalent to RNase IIIb hot spot mutations that cause GLOW syndrome [12]. (A higher resolution/colour version of this figure is available in the electronic copy of the article).
