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. Author manuscript; available in PMC: 2021 Aug 30.
Published in final edited form as: Microrna. 2020;9(1):70–80. doi: 10.2174/2211536608666190624114424

Fig. (8).

Fig. (8).

Specific increased 3p miRNAs target mTOR signaling. We show that certain miRNAs affected by these pathogenic mutations target negative regulators of mTOR: namely TSC2. Additionally, downstream targets are affected which streamlines mTOR signaling into S6kinase activation of cell proliferation/growth. We have provided evidence for this via the increased pS6Kinase levels on our DICER1delExon25 (+/−) cell model. (A higher resolution/colour version of this figure is available in the electronic copy of the article).