Fig.6.

mRNA expression levels of CSPG4, MMP-13, Versican, ERK, JNK and MAPK p38 in chondrocytes as analysed by real-time quantitative polymerase chain reaction (RT-qPCR). Control group: chondrocytes cultured in Dulbecco’s Modified Eagle’s Medium (DMEM), IL-1β group; chondrocytes cultured in DMEM with 10 ng/ml IL-1β for 24 hours followed by exposure to 0 μg/ml exosomes for 48 hours, IL-1β+EXOs group: chondrocytes cultured in DMEM with 10 ng/ml IL-1β for 24 hours and then exposed to 10 μg/ml exosomes for 48 hours. *; P<0.05 compared with the control group, **; P<0.01 compared with the control group, #; P<0.05 compared with the IL-1β group, and ##; P<0.01 compared with the IL-1β group.