Table 4.
Mixed effects model.
| GFR |
|
|---|---|
| Mean (SD) | |
| Years post transplant | –1.8 (–2.0, −1.6)** |
| Increase in UA of 1 mg/dL | –0.73 (–1.9, 0.4) |
| Age (increase in 1 year) | 0.02 (–0.13, 0.17) |
| Female (vs. male) | –0.64 (–4.4, 3.1) |
| Race | |
| White | Reference |
| Black | –5.5 (–10.4, −0.7)* |
| Other | –3.5 (–8.5, 1.4) |
| Transplant type | |
| DCD/ECD vs. LRD/LURD | 2.2 (–3.27, 7.7) |
| SCD vs. LRD/LURD | 0.9 (–4.4, 6.2) |
| Induction | |
| Thymoglobulin | Reference |
| Simulect | –1.37 (–5.2, 2.4) |
| No induction | 3.6 (–12.9, 20.1) |
| Medical history | |
| Hypertension | –2.2 (–9.0, 4.7) |
| Heart Failure | –2.6 (–6.7, 1.6) |
| Cardiovascular disease | –6.3 (–10.2, −2.4)** |
| Pre-transplant diabetes | –2.6 (–6.5, 1.4) |
| Median CNI trough level | 0.87 (–0.2, 1.97) |
| CNI coefficient of variation | –0.09 (–0.2, 0.02) |
| Use of loop diuretics | –3.1 (–7.6, 1.5) |
| SGF vs. no SGF | 0.5 (–4.2, 5.2) |
| GFR_3M increase in 1 ml/min | 0.6 (0.5, 0.72)** |
Note: The results shown in the table were derived from 4 separate linear regression models; each of them adjusted for the following covariates: age, race, gender, transplant type, induction therapy, medical history, median and coefficient of variance CNI trough level, use of loope diuretics, pre-transplant diabetes, presence of SGF and baseline GFR. *p < 0.05; **p < 0.01.