Table 5.
Multivariate cox regression hazard model for death-censored graft loss.
| HR |
|
|---|---|
| Mean (95% CI) | |
| Years post-transplant | 0.99 (0.96, 1.02) |
| Increase in UA of 1 mg/dL | 1.3 (1.0, 1.7)* |
| Age (increase in 1 year) | 0.99 (0.96, 1.02) |
| Female (vs. male) | 0.8 (0.32, 1.9) |
| Race | |
| White | Reference |
| Black | 3.28 (1.2, 9.1)* |
| Other | 2.2 (0.7, 7.2) |
| Transplant type | |
| DCD/ECD vs. LRD/LURD | 0.5 (0.1, 1.7) |
| SCD vs. LRD/LURD | 0.4 (0.1, 1.4) |
| Induction | |
| Thymoglobulin | Reference |
| Simulect | 1.8 (0.78, 4.31) |
| No induction | 1.05 (0.07, 14.91) |
| Medical history | |
| Hypertension | 1.5 (0.17, 13.5) |
| Heart failure | 2.06 (0.8, 5.5) |
| Cardiovascular disease | 1.24 (0.46, 3.34) |
| Pre-transplant diabetes | 0.7 (0.3, 1.75) |
| Median CNI trough level | 1.0 (0.8, 1.3) |
| CNI coefficient of variation | 1.04 (1.02, 1.1)** |
| Use of loop diuretics | 0.94 (0.36, 2.4) |
| SGF vs. no SGF | 0.65 (0.2, 1.95) |
| GFR_3M increase in 1 ml/min | 0.96 (0.93, 1.00)* |
Note: The results shown in the table were derived from 4 separate multivariate Cox regression hazard models; each of them adjusted for the following covariates: age, race, gender, transplant type, induction therapy, medical history, median and coefficient of variance CNI trough level, use of loope diuretics, pre-transplant diabetes, presence of SGF and baseline GFR. *p < 0.05; **p < 0.01.