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. Author manuscript; available in PMC: 2021 Aug 30.
Published in final edited form as: J Tissue Eng Regen Med. 2011 Feb 24;6(2):144–154. doi: 10.1002/term.408

Figure 6.

Figure 6.

Real-time PCR of osteogenic markers for OA chondrocytes cultured with MMP inhibitors; *statistical significance from control or 0 μM, unless otherwise specified; n = 3. (A–C) When OA chondrocytes were cultured in growth medium, cbfa-1 and osteopontin were significantly downregulated in the presence of all concentrations of MMPis. Bone sialoprotein was only decreased at the highest concentration. (D, E) After culture in chondrogenic medium with TGFβ1, both cbfa-1 and osteopontin demonstrated increasing trends in the presence of MMPis, with the most significant changes in osteopontin