Table 2.
PPV and NPV for all patients and those with anemia, neutropenia, and thrombocytopenia, also demonstrated for patients with bicytopenia and pancytopenia
| MDS, n (%) | No MDS, n (%) | PPV, % [95% CI] | NPV, % [95% CI] | |
|---|---|---|---|---|
| Total (all patients) | 502 (100) | 502 (100) | 88.4 [79.9, 93.6] | 94.3 [93.4, 95.2] |
| Cytopenia: WHO * | ||||
| Anemia | 454 (90.44) | 354 (70.52) | 85.0 [74.8, 91.6] | 94.8 [93.8, 95.7] |
| Neutropenia | 178 (35.46) | 66 (13.20) | 73.4 [51.5, 87.8] | 97.4 [95.9, 98.4] |
| Thrombocytopenia | 210 (41.83) | 174 (34.66) | 86.8 [67.9, 95.3] | 93.2 [91.6, 94.5] |
| Bicytopenia | 184 (36.65) | 112 (22.40) | 82.2 [60.2, 93.5] | 93.3 [91.5, 94.8] |
| Pancytopenia | 83 (16.53) | 31 (6.20) | 72.3 [40.4, 91.0] | 98.2 [95.7, 99.2] |
| Severe cytopenia: IPSS † | ||||
| Anemia | 244 (48.61) | 151 (30.08) | 85.7 [69.4, 94.1] | 95.7 [94.3, 96.8] |
| Neutropenia | 135 (26.89) | 48 (9.60) | 89.1 [54.0, 98.3] | 97.6 [95.7, 98.6] |
| Thrombocytopenia | 124 (24.70) | 103 (20.52) | 90.0 [60.9, 96.3] | 93.8 [91.7, 95.4] |
| Bicytopenia | 94 (18.73) | 41 (8.20) | 84.1 [48.7, 93.9] | 96.9 [94.6, 98.2] |
| Pancytopenia | 25 (4.98) | 9 (1.80) | 57.5 [21.5, 79.8] | 97.5 [90.8, 99.4] |
IPSS, International Prognostic Scoring System; WHO, World Health Organization.
*
Cytopenia according to WHO criteria: anemia (hemoglobin: <12 g/dL, women; <13 g/dL, men), neutropenia (absolute neutrophil count, <1.8 × 109/L), and thrombocytopenia (platelets, <150 × 109/L).
†
Severe cytopenia, using IPSS criteria: anemia (hemoglobin, <10 g/dL), neutropenia (absolute neutrophil count, <1.5 × 109/L), and thrombocytopenia (platelets, <100 × 109/L).