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Comparison of the transcriptomic profiles of WT and mutant-BTK–overexpressing cells. (A-C) Volcano plots comparing MEC-1 cells overexpressing BTKWT and BTKC481S (A), BTKWT and BTKC481R (B), and BTKC481S and BTKC481R (C). The DEGs (FDR, ≤0.05; fold change, >2 or < −2) are labeled in red. (D-F) Heat maps of the DEGs (FDR, ≤0.05; fold change, >2 or <−2) between MEC-1 cells overexpressing BTKWT and BTKC481S (D), BTKWT and BTKC481R (E), or BTKC481S and BTKC481R (F).
