Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 20;5(16):3174–3187. doi: 10.1182/bloodadvances.2020003811

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by The American Society of Hematology

PMC Copyright notice

Figure 3. — Normal engraftment and multilineage differentiation of ADA2-transduced HDs’ CD34⁺ cells in NSGW41 mice. (A) The average VCN per genome was evaluated in ADA2- and GFP-transduced HSPCs expanded in vitro (LC), in total peripheral blood leukocytes at 7, 14, and 20 weeks posttransplant, and at 20 weeks in the BM and spleen (SPL) of NSGW41 mice receiving LV-ADA2– or LV-GFP–transduced lineage-negative cells (n = 6 mice per group). Longitudinal analysis of human cell chimerism (CD45⁺ cells; B) and B, T, myeloid, and NK cells (C) in peripheral blood at 7, 14, and 20 posttransplantation. (D) Flow cytometry analysis showing the total number of HSCs and various progenitor populations in the BM of NSGW41 mice. Data are mean ± standard error. **P < .01, ***P < .001. iGranulo, immature granulocytes; mGranulo, mature granulocytes.