Table 1.
Demographic and Clinical Data of Participants
| Controls (n=30) | MDD (n=30) | F/t/x2 | P | ||
|---|---|---|---|---|---|
| Pre-Treatment | Post-Treatment | ||||
| Age (years) | 36.40±14.04 | 35.63±15.10 | NA | −0.204 | 0.806a |
| Age of onset (years) | NA | 33.93±15.38 | NA | NA | NA |
| Gender (M/F) | 8/22 | 7/23 | NA | 0.089 | 0.766b |
| Education (years) | 13.77±4.26 | 11.63±4.17 | NA | −1.958 | 0.055a |
| BMI | 22.88±2.97 | 22.22±3.57 | NA | −0.784 | 0.436a |
| Marital status (Single/Married/Divorce) | 15/14/1 | 11/18/1 | NA | 1.115 | 0.573b |
| Total duration of illness (months) | NA | 21.90±27.36 | NA | NA | NA |
| Duration of illness this time (months) | NA | 13.80±22.75 | NA | NA | NA |
| Episodes | NA | 1.17±0.38 | NA | NA | NA |
| HAMD-17 | 1.07±1.55 | 21.23±3.52* | 7.45±4.16*# | 299.47 | <0.001c |
| HAMD-A/S | 6.37±1.65 | 2.38±1.30 | 14.242 | <0.001d | |
| HAMD-R | 6.80±1.67 | 2.97±1.55 | 16.250 | <0.001d | |
| HAMD-CD | 2.97±1.65 | 0.97±1.32 | 7.620 | <0.001d | |
| HAMD-SLD | 3.87±1.87 | 0.86±0.88 | 10.649 | <0.001d | |
| HAMD-W | 0.53±0.78 | 0.00±0.00 | 3.794 | 0.001d | |
| HAMA | 0.73±1.02 | 18.93±4.73* | 6.24±4.11*# | 194.699 | <0.001c |
| HAMA-PSA | 13.13±2.95 | 4.93±2.75 | 18.029 | <0.001d | |
| HAMA-PHA | 5.80±3.30 | 1.31±1.82 | 8.830 | <0.001d | |
Notes: aIndependent samples t-test; bChi-square test; cOne-way ANOVA; dPaired-samples t-test. *P < 0.001 compared with HC group; #P < 0.001 compared with Pre-treatment MDD group.
Abbreviations: MDD, major depressive disorder; HC, healthy control; M/F, male/female; BMI, body mass index; HAMD-17, 17-item Hamilton Depression Rating Scale; HAMD-A/S, Hamilton Depression Rating Scale-Anxiety/somatization factor; HAMD-R, Hamilton Depression Rating Scale-Retardation factor; HAMD-CD, Hamilton Depression Rating Scale-Cognitive disorder factor; HAMD-SLD, Hamilton Depression Rating Scale-Sleep disorder factor; HAMD-Weight, Hamilton Depression Rating Scale-Weight factor; HAMA, Hamilton Anxiety Rating Scale; HAMA-PSA, Hamilton Anxiety Rating Scale-Psychological anxiety factor; HAMA-PHA, Hamilton Anxiety Rating Scale-Physical anxiety factor; BDNF, brain-derived neurotrophic factor; CRP, C-reactive protein; IL-10, interleukin-10; IFN-gamma, interferon-gamma; NA, Not Available.