Table 2.
Histologic features of liver biopsies in patients on immune checkpoint inhibitors (n = 60).
| Feature | n |
|---|---|
| Hepatitic pattern | 36 |
| Zonation of lobular injury | |
| Centrilobular predominance | 20 |
| Azonal | 10 |
| Panlobular | 4 |
| Periportal | 2 |
| Portal inflammation | |
| None to mild | 22 |
| Moderate | 14 |
| Prominent portal inflammatory cell composition | |
| Mononuclear cells with or without eosinophils | 21 |
| Mononuclear, +/− eosinophils, and pericholangitis | 13 |
| No significant inflammation | 2 |
| Granulomas | 16 |
| Loose histiocytic aggregates | 12 |
| Fibrin ring type | 6 |
| Well-formed | 2 |
| Endothelialitis | 14 |
| Central vein endothelialitis | 14 |
| Portal vein endothelialitis | 4 |
| Steatosis (mild to moderate) | 16 |
| Localized to lobular injury | 7 |
| Cholangiopathic pattern | 16 |
| Duct injury | 16 |
| Mild | 4 |
| Moderate | 11 |
| Marked | 1 |
| Portal inflammation | |
| Mild | 6 |
| Moderate | 10 |
| Prominent portal inflammatory cell composition | |
| Mononuclear cells with or without eosinophils | 2 |
| Mononuclear, +/− eosinophils, and pericholangitis | 3 |
| Predominantly neutrophil pericholangitis | 11 |
| Granulomas | 1 |
| Endothelialitis | 0 |
| Steatosis (mild to moderate) | 3 |
| Localized to lobular injury | 0 |
| Steatotic pattern | 4 |
| Mild steatosis | 1 |
| Moderate steatosis | 3 |
| Fibrosis or cirrhosis | 2 |
| Mild non-specific changes | 4 |