Figure 5.

The impairment of hippocampal synaptic plasticity was induced by chronic IH treatment (7 and 14 days) which was associated with the increased expression of CHOP. GSK2606414 could rescue this impairment. (a) GSK2606414 prevented chronic IH-induced impairment in hippocampal LTP. (b) Quantification of the results shown in A. (c) hippocampal synaptic plasticity was not impaired after 2 or 3 days of IH treatment. (d) Quantification of the results shown in C. (e) Representative western blots showed that the expression of CHOP was not increased in hippocampal tissue after 2 or 3 days of IH exposure. The pooled data from three mice for each group are summarized in (f). ^∗P < 0.05; ^∗∗P < 0.01; ^∗∗∗P < 0.001; ns: not significant.