Skip to main content
. 2021 Aug 21;2021:4090441. doi: 10.1155/2021/4090441

Figure 6.

Figure 6

GSK2606414 rescued IH-induced memory impairment. (a) Anxiety levels were assessed using the open-field test. Three concentric areas of the open arena were defined. (b) The amounts of time animals spent in different areas did not differ among groups. (c) The animals in the different groups showed no preference for one object over another identical object during the training phase. (d) The percentage of time spent exploring the novel object was significantly reduced in the IH group during the trial phase 24 h after training. The higher preference for the novel object was restored by GSK2606414. ∗P < 0.05; ∗∗P < 0.01. (e) The escape latencies were increased in the IH group on the fourth day and were reduced by GSK2606414. ∗∗P < 0.01 control vs. IH; #P < 0.05 IH vs. IH + GSK2606414. (f) IH increased the number of attempts required to find the platform, and this effect was reduced by GSK2606414. ∗P < 0.05; ∗∗P < 0.01; ns: not significant.