. 2021 Aug 21;2021:7077344. doi: 10.1155/2021/7077344

Table 3.

The correlation between the AME gene profile of P. aeruginosa clinical isolates and the MIC ranges of aminoglycosides.

Genotypes	No. (%) of MDRs	No. (%) of isolates with different MICs (μg/ml) against amikacin				No. (%) of isolates with different MICs (μg/ml) against gentamicin				No. (%) of isolates with different MICs (μg/ml) against tobramycin				No. (%) of isolates with different MICs (μg/ml) against netilmicin
Genotypes	No. (%) of MDRs	≤16	32	64-128	≥256	≤4	8	16-128	≥256	≤4	8	16-128	≥256	≤8	16	32-128	≥256
ANT(3^″)-Ia (n = 8)	7 (87.5)	5 (62.5)	1 (12.5)	0	2 (25)	1 (12.5)	0	2 (25)	5 (62.5)	1 (12.5)	0	6 (75)	1 (12.5)	1 (12.5)	0 (0)	7 (87.5)	0
ANT(2^″)-Ia (n = 6)	5 (83.3)	2 (33.3)	2 (33.3)	2 (33.3)	0	0	0	2 (33.3)	4 (66.6)	0	0	4 (66.6)	2 (33.3)	1 (16.6)	1 (16.6)	3 (50)	1 (16.6)
AAC(6′)-Ib (n = 26)	24 (92.3)	11 (42.3)	4 (15.3)	7 (26.9)	4 (15.3)	1 (3.8)	1 (3.8)	3 (11.5)	21 (80.7)	1 (3.8)	0	12 (46.1)	13 (50)	3 (11.5)	0	18 (69.2)	5 (19.2)
AAC(6′)-IIa (n = 18)	16 (88.8)	10 (55.5)	3 (16.6)	3 (16.6)	2 (11.1)	2 (11.1)	1 (5.5)	4 (22.2)	11 (61.1)	2 (11.1)	0	10 (55.5)	6 (33.3)	4 (22.2)	0	12 (66.6)	2 (11.1)
APH(3′)-IIb (n = 15)	13 (86.6)	7 (46.6)	3 (20)	3 (20)	2 (13.3)	1 (6.6)	0	4 (26.6)	10 (66.6)	1 (6.6)	0	9 (60)	5 (33.3)	2 (13.3)	1 (6.6)	10 (66.6)	2 (13.3)
APH(3^″)-Ib (n = 1)	0	1 (100)	0	0	0	0	0	1 (100)	0	0	0	1 (100)	0	0	1 (100)	0	0
ANT(3^″)-Ia+ ANT(2^″)Ia (n = 2)	2 (100)	1 (50)	1 (50)	0	0	0	0	1 (50)	1 (50)	0	0	1 (50)	1 (50)	1 (50)	0	1 (50)	0
ANT(3^″)-Ia+ AAC(6′)-Ib (n = 6)	5 (83.3)	4 (66.6)	1 (16.6)	0	1 (16.6)	0	0	2 (33.3)	4 (66.6)	0	0	5 (83.3)	1 (16.6)	1 (16.6)	0	5 (83.3)	0
ANT(3^″)-Ia+ AAC(6′)-IIa (n = 3)	2 (66.6)	2 (66.6)	1 (33.3)	0	0	0	0	1 (33.3)	2 (66.6)	0	0	2 (66.6)	1 (33.3)	1 (33.3)	0	2 (66.6)	0
ANT(3^″)-Ia+ APH(3′)-IIb (n = 4)	3 (75)	2 (50)	1 (25)	0	1 (25)	0	0	1 (25)	3 (75)	0	0	3 (75)	1 (25)	1 (25)	0	3 (75)	0
ANT(2^″)-Ia+ AAC(6′)-Ib (n = 5)	5 (100)	1 (20)	2 (40)	2 (40)	0	0	0	1 (20)	4 (80)	0	0	2 (40)	3 (60)	1 (20)	0	3 (60)	1 (20)
ANT(2^″)-Ia+ AAC(6′)-IIa (n = 5)	5 (100)	1 (20)	2 (40)	2 (40)	0	0	0	1 (20)	4 (80)	0	0	2 (40)	3 (60)	1 (20)	0	3 (60)	1 (20)
ANT(2^″)-Ia+ APH(3′)-IIb (n = 6)	5 (83.3)	2 (33.3)	2 (33.3)	2 (33.3)	0	0	0	2 (33.3)	4 (66.6)	0	0	3 (50)	3 (50)	1 (16.6)	1 (16.6)	3 (50)	1 (16.6)
ANT(2^″)-Ia+ APH(3^″)-Ib (n = 1)	0	1 (100)	0	0	0	0	0	1 (100)	0	0	0	1 (100)	0	0	1 (100)	0	0
AAC(6′)-Ib+ AAC(6′)-IIa (n = 14)	12 (85.7)	7 (50)	2 (14.2)	3 (21.4)	2 (14.2)	0	1 (7.1)	2 (14.2)	11 (78.5)	0	0	8 (57.1)	6 (42.8)	3 (21.4)	0	9 (64.2)	2 (14.2)
AAC(6′)-Ib+ APH(3′)-IIb (n = 9)	8 (88.8)	3 (33.3)	2 (22.2)	3 (33.3)	1 (11.1)	0	0	1 (11.1)	8 (88.8)	0	0	5 (55.5)	4 (44.4)	1 (11.1)	0	6 (66.6)	2 (22.2)
AAC(6′)-IIa+ APH(3′)-IIb (n = 12)	11 (91.66)	5 (41.6)	3 (25)	3 (25)	1 (8.3)	1 (8.3)	0	3 (25)	8 (66.6)	1 (8.3)	0	7 (58.3)	4 (33.3)	2 (16.6)	0	8 (66.6)	2 (16.6)
APH(3′)-IIb+ APH(3′′)-Ib (n = 1)	0	1 (100)	0	0	0	0	0	1 (100)	0	0	0	1 (100)	0	0	1 (100)	0	0
ANT(3^″)-Ia+ ANT(2^″)-Ia+ AAC(6′)-Ib (n = 2)	2 (100)	1 (50)	1 (50)	0	0	0	0	1 (50)	1 (50)	0	0	1 (50)	1 (50)	1 (50)	0	1 (50)	0
ANT(3^″)-Ia+ ANT(2^″)-Ia+ AAC(6′)-IIa (n = 2)	2 (100)	1 (50)	1 (50)	0	0	0	0	1 (50)	1 (50)	0	0	1 (50)	1 (50)	1 (50)	0	1 (50)	0
ANT(3^″)-Ia+ ANT(2^″)-Ia+ APH(3)-IIb (n = 2)	2 (100)	1 (50)	1 (50)	0	0	0	0	1 (50)	1 (50)	0	0	1 (50)	1 (50)	1 (50)	0	1 (50)	0
ANT(3^″)-Ia+ APH(3)-IIb+ AAC(6′)-Ib (n = 3)	2 (66.6)	2 (66.6)	1 (33.3)	0	0	0	0	1 (33.3)	2 (66.6)	0	0	0	0	1 (33.3)	0	2 (66.6)	0
ANT(3^″)-Ia+ APH(3′)-IIb+ AAC(6′)-IIa (n = 3)	2 (66.6)	2 (66.6)	1 (33.3)	0	0	0	0	1 (33.3)	2 (66.6)	0	0	2 (66.6)	1 (33.3)	1 (33.3)	0	2 (66.6)	0
ANT(3^″)-Ia+ AAC(6′)-Ib+ AAC(6′)-IIa (n = 3)	2 (66.6)	2 (66.6)	1 (33.3)	0	0	0	0	1 (33.3)	2 (66.6)	0	0	2 (66.6)	1 (33.3)	1 (33.3)	0	2 (66.6)	0
ANT(2^″)-Ia+ APH(3′)-IIb+ AAC(6′)-Ib (n = 5)	5 (100)	1 (20)	2 (40)	2 (40)	0	0	0	1 (20)	4 (80)	0	0	3 (60)	2 (40)	1 (20)	0	3 (60)	1 (20)
ANT(2^″)-Ia+ AAC(6′)-Ib+ AAC(6′)-IIa (n = 5)	5 (100)	1 (20)	2 (40)	2 (40)	0	0	0	1 (20)	4 (80)	0	0	3 (60)	2 (40)	1 (20)	0	3 (60)	1 (20)
APH(3′)-IIb+ AAC(6′)-Ib+ AAC(6′)-IIa (n = 9)	8 (88.8)	3 (33.3)	2 (22.2)	3 (33.3)	1 (11.1)	0	0	1 (11.1)	8 (88.8)	0	0	5 (55.5)	4 (44.4)	1 (11.1)	0	6 (66.6)	2 (22.2)
ANT(2^″)-Ia+ APH(3′)-IIb+ APH(3^″)-Ib (n = 1)	0	1 (100)	0	0	0	0	0	1 (100)	0	0	0	1 (100)	0	0	1 (100)	0	0
ANT(3^″)-Ia+ ANT(2^″)-Ia+ APH(3′)-IIb+ AAC(6′)-Ib (n = 2)	2 (100)	1 (50)	1 (50)	0	0	0	0	1 (50)	1 (50)	0	0	1 (50)	1 (50)	1 (50)	0	1 (50)	0
ANT(2^″)-Ia+ APH(3′)-IIb+ AAC(6′)-Ib+ AAC(6′)-IIa (n = 5)	5 (100)	1 (20)	2 (40)	2 (40)	0	0	0	1 (20)	4 (80)	0	0	3 (60)	2 (40)	1 (20)	0	3 (60)	1 (20)
ANT(3^″)-Ia+ APH(3′)-IIb+ AAC(6′)-Ib+ AAC(6′)-IIa (n = 3)	2 (66.6)	2 (66.6)	1 (33.3)	0	0	0	0	1 (33.3)	2 (66.6)	0	0	2 (66.6)	1 (33.3)	1 (33.3)	0	2 (66.6)	0
ANT(3^″)-Ia+ ANT(2^″)-Ia+ AAC(6′)-Ib+ AAC(6′)-IIa (n = 2)	2 (100)	1 (50)	1 (50)	0	0	0	0	1 (50)	1 (50)	0	0	1 (50)	1 (50)	1 (50)	0	1 (50)	0
ANT(3^″)-Ia+ ANT(2^″)-Ia+ APH(3′)-IIb+ AAC(6′)-IIa (n = 2)	2 (100)	1 (50)	1 (50)	0	0	0	0	1 (50)	1 (50)	0	0	1 (50)	1 (50)	1 (50)	0	1 (50)	0
ANT(3^″)-Ia+ ANT(2^″)-Ia+ APH(3′)-IIb+ AAC(6′)-Ib+ AAC(6′)-IIa (n = 2)	2 (100)	1 (50)	1 (50)	0	0	0	0	1 (50)	1 (50)	0	0	1 (50)	1 (50)	1 (50)	0	1 (50)	0