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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Curr Opin Struct Biol. 2021 Apr 14;69:41–49. doi: 10.1016/j.sbi.2021.03.001

Figure 1.

Figure 1.

Evolution of CDT activity in a non-catalytic protein. (a) The reaction catalyzed by CDT. (b) A phylogenetic tree connecting extant CDTs and related amino-acid binding proteins. Yellow, affinity for cationic amino acids; grey, affinity for negatively charged ligands; green, CDT activity. (c) Comparison of the ligand binding site of AncCDT1 (purple) and the active site of extant P. aeruginosa CDT (grey). Reprinted by permission from Springer Nature Nature Chemical Biology 14:542–547, Evolution of cyclohexadienyl dehydratase from an ancestral solute-binding protein, Clifton BE, Kaczmarski JA, Carr PD, Gerth ML, Tokuriki N, Jackson CJ.