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. 2021 Jun 17;48(5):725–741. doi: 10.1007/s10928-021-09768-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Model evaluation of the rat LeiCNS-PK3.0 model. Visual predictive checks plots compared in vivo measured drug concentration (black dots) in multiple CNS locations to the median (solid line) and 95% prediction intervals (colored band) of 200 model simulations. ECF brain extracellular fluid, LV lateral ventricles, CM cisterna magna, BH brain homogenate (Color figure online)