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Pharmacokinetic profiles of acetaminophen at brain extracellular (ECF) fluid and subarachnoid space (SAS) at physiological and a two- and b five-fold altered cerebrospinal fluid (CSF) volume and flow. Changing CSF dynamics affects SAS pharmacokinetics and not brain ECF pharmacokinetics. ECF brain extracellular fluid, SAS subarachnoid space
