Table 1.

Cerebrospinal fluid dynamics in different CNS disease conditionsa

	Aginga	Alzheimer's disease	Hydrocephalus	Traumatic brain injurya
CSF volume	400%	150%b	150%b	115%
	[51]	[52]	[53]	[54]
CSF production	66%	46%a	60%b
	[55]	[56]	[57]
CSF flow	150%	Normal CSF flowa	370% and reverse flow directiona
	[58]	[59]	[32]
CSF clearance	Reduced CSF absorptionc	65%b	20–60%a
	[60]	[61]	[62]

^aCompared to adults (< 60 years)

^bCompared to elderly (60 + years)

^cA study in rats