Table 1.

Baseline demographic and clinical characteristics of deceased vs. living ET cases.

	All ET Cases N = 194	Deceased N = 52	Living N = 142	Significance (Deceased vs. Living)
Age (years)	79.1 ± 9.7	88.0 ± 5.1	75.9 ± 8.9	p < 0.001 a
Female	118 (60.8)	32 (61.5)	86 (60.6)	p = 0.90b
White race	189 (97.4)	52 (100.0)	137 (96.5)	p = 1.00c
Education (years)	15.9 ± 2.5	15.3 ± 2.8	16.1 ± 2.4	p = 0.07a
Number of prescription medications	5.7 ± 4.0 [5.0]	7.3 ± 4.7 [6.0]	5.1 ± 3.6 [5.0]	p = 0.002 d
Current cigarette smoker	8 (4.1)	1 (1.9)	7 (4.9)	p = 0.68c
Age of tremor onset (years)	39.7 ± 22.4 [40.0]	44.8 ± 24.6 [50.0]	37.8 ± 21.4 [40.0]	p = 0.06d
Tremor duration (years)	39.3 ± 22.1 [34.0]	43.2 ± 24.4 [34.0]	37.8 ± 21.1 [33.0]	p = 0.20d
Total tremor score	20.1 ± 5.0	21.6 ± 5.4	19.6 ± 4.8	p = 0.02 a
MoCA score	24.6 ± 3.6	22.0 ± 4.5	25.5 ± 2.8	p < 0.001 a
MMSE score	28.2 ± 2.7	26.1 ± 4.1	29.0 ± 1.4	p < 0.001 a
Cognitive diagnosis*				p < 0.001 b
Normal cognition	148 (76.3)	26 (50.0)	122 (85.9)
MCI	29 (14.9)	13 (25.0)	16 (11.3)
Dementia	15 (7.7)	13 (25.0)	2 (1.4)
CDR				p < 0.001 b
0	136 (70.1)	24 (46.2)	112 (78.9)
0.5	43 (22.2)	15 (28.8)	28 (19.7)
1	11 (5.7)	9 (17.3)	2 (1.4)
2	4 (2.1)	4 (7.7)	0 (0.0)
3	0 (0.0)	0 (0.0)	0 (0.0)
Cognitive domain
Memory	−0.11 ± 0.99	−0.77 ± 1.07	0.14 ± 0.84	p < 0.001 a
Executive function	−0.01 ± 0.72	−0.40 ± 0.91	0.14 ± 0.57	p < 0.001 a
Attention	−0.29 ± 0.75	−0.56 ± 0.75	−0.20 ± 0.73	p = 0.004 a
Visuospatial abilities	0.48 ± 0.71	0.32 ± 0.76	0.54 ± 0.69	p = 0.06a
Language	0.03 ± 0.62 [0.09]	−0.14 ± 0.86 [−0.04]	0.09 ± 0.50 [0.11]	p = 0.12d
GDS	6.4 ± 5.2 [5.0]	7.0 ± 5.1 [7.0]	6.2 ± 5.2 [5.0]	p = 0.21d
Number of falls reported in the past year	1.4 ± 3.3 [0.0]	2.1 ± 4.6 [1.0]	1.1 ± 2.7 [0.0]	p = 0.005 d
Number of tandem missteps	5.3 ± 4.1 [5.0]	8.7 ± 2.8 [10.0]	4.1 ± 3.8 [3.0]	p < 0.001 d
PASE score	96.8 ± 71.3 [85.0]	52.3 ± 40.0 [36.8]	108.9 ± 73.2 [97.4]	p < 0.001 d
PSQI item: average hours of sleep	7.2 ± 1.4	7.2 ± 1.8	7.2 ± 1.2	p = 0.81a
PSQI item: Sleep quality	0.90 ± 0.77 [1.0]	0.88 ± 0.74 [1.0]	0.90 ± 0.78 [1.0]	p = 0.98d

Values are number (percentage) or mean ± standard deviation [median]. Percentages are column percentages.

^*2 individuals had cognitive impairment that was not classified as MCI or dementia. Bolded values are statistically significant (p < 0.05).

CDR, Clinical Dementia Rating; ET, essential tremor; GDS, Geriatric Depression Scale; MCI, mild cognitive impairment; MMSE; Mini-Mental State Exam; MoCA, Montreal Cognitive Assessment; PASE, Physical Activity Scale for the Elderly; PSQI, Pittsburgh Sleep Quality Index.

^aStudent’s t-test

^bChi-square test

^cFisher’s exact test

^dMann-Whitney U test