Table 1.
Characteristics of the postmenopausal women with osteopenia, osteoporosis and controls taking part in the study of the UGT1A1*28 genetic variant.
| Genotype | 6/6 | 6/7 | 7/7 | |
|---|---|---|---|---|
| Osteopenia | ||||
| Mean ± SD n = 43 |
Mean ± SD n = 46 |
Mean ± SD n = 20 |
p | |
| Age (years) | 52.211 ± 7.117 | 53.727 ± 9.197 | 53.842 ± 6.702 | 0.543 |
| T-score | − 1.828 ± 0.706 | − 1.841 ± 0.065 | − 1.720 ± 0.097 | 0.425 |
| Z-score | − 0.921 ± 0.114 | − 0.808 ± 0.118 | − 0.816 ± 0.227 | 0.354 |
| Body mass (kg) | 66.438 ± 1.712 | 64.954 ± 1.801 | 63.526 ± 1.714 | 0.243 |
| BMI (kg/m2) | 24.665 ± 0.581 | 24.553 ± 0.701 | 24.357 ± 0.684 | 0.455 |
| Birth weight (g) | 3169.166 ± 106.546 | 3306.667 ± 90.707 | 3356.032 ± 319.352 | 0.365 |
| Years of reproduction | 35.791 ± 5.021 | 36.727 ± 4.311 | 36.300 ± 6.766 | 0.244 |
| Age of first menstruation | 12.791 ± 2.734 | 13.045 ± 2.126 | 13.500 ± 2.368 | 0.436 |
| Age of last menstruation | 48.500 ± 4.338 | 50.103 ± 4.512 | 49.571 ± 5.139 | 0.432 |
| Years after menopause | 6.500 ± 4.428 | 7.810 ± 6.214 | 6.400 ± 7.411 | 0.542 |
| BMD L2–L4 (g/cm2) | 0.947 ± 0.054 | 0.964 ± 0.028 | 1.016 ± 0.031 | 0.632 |
| BMD L2–L4 YA (%) | 76.838 ± 2.324 | 83.325 ± 2.510 | 80.166 ± 7.211 | 0.268 |
| BMD L2–L4 AM (%) | 86.720 ± 2.042 | 89.194 ± 2.931 | 92.823 ± 2.753 | 0.366 |
| Osteoporosis | ||||
|---|---|---|---|---|
| Mean ± SD n = 129 |
Mean ± SD n = 154 |
Mean ± SD n = 50 |
p | |
| Age (years) | 56.227 ± 8.189 | 56.857 ± 8.256 | 57.222 ± 11.074 | 0.542 |
| T-score | − 3.319 ± 0.097 | − 3.081 ± 0.074 | − 3.223 ± 0.219 | 0.326 |
| Z-score | − 1.966 ± 0.242 | − 1.577 ± 0.125 | − 1.839 ± 0.233 | 0.096 |
| Body mass (kg)* | 60.379 ± 1.265 | 60.325 ± 1.204 | 66.833 ± 2.023 | 0.045 |
| BMI (kg/m2) | 23.407 ± 0.551 | 23.567 ± 0.479 | 25.538 ± 0.570 | 0.243 |
| Birth weight (g) | 3233.333 ± 231.142 | 3155.714 ± 227.165 | 3050.012 ± 354.101 | 0.344 |
| Years of reproduction | 34.900 ± 5.379 | 35.575 ± 5.131 | 36.909 ± 4.276 | 0.348 |
| Age of first menstruation | 12.650 ± 2.580 | 13.393 ± 2.014 | 11.905 ± 1.375 | 0.632 |
| Age of last menstruation | 46.111 ± 5.514 | 49.052 ± 4.645 | 48.667 ± 4.313 | 0.472 |
| Years after menopause | 12.100 ± 4.428 | 9.666 ± 5.374 | 11.454 ± 4.612 | 0.266 |
| BMD L2–L4 (g/cm2) | 0.985 ± 0.023 | 0.972 ± 0.028 | 0.983 ± 0.032 | 0.282 |
| BMD L2–L4 YA (%) | 82.184 ± 1.927 | 81.065 ± 2.324 | 81.933 ± 2.708 | 0.362 |
| BMD L2–L4 AM (%) | 90.315 ± 2.007 | 89.239 ± 2.141 | 90.133 ± 3.421 | 0.423 |
| Controls | ||||
|---|---|---|---|---|
| Mean ± SD n = 88 |
Mean ± SD n = 120 |
Mean ± SD n = 25 |
p | |
| Age (years) | 54.632 ± 5.041 | 53.247 ± 8.736 | 52.428 ± 13.044 | 0.442 |
| T-score | 0.045 ± 0.234 | 0.149 ± 0.161 | − 0.002 ± 0.371 | 0.096 |
| Z-score | 0.687 ± 0.158 | 0.782 ± 0.277 | 0.042 ± 0.343 | 0.064 |
| Body mass (kg) | 68.045 ± 2.241 | 70.212 ± 2.228 | 64.571 ± 2.930 | 0.142 |
| BMI (kg/m2) | 25.741 ± 0.887 | 26.431 ± 0.947 | 25.139 ± 1.217 | 0.352 |
| Birth weight (g) | 3587.272 ± 55.176 | 3750.546 ± 343.016 | 3495.500 ± 66.272 | 0.426 |
| Years of reproduction | 35.810 ± 5.221 | 36.416 ± 5.122 | 38.509 ± 6.256 | 0.466 |
| Age of first menstruation | 13.550 ± 1.780 | 13.323 ± 1.816 | 13.255 ± 2.775 | 0.482 |
| Age of last menstruation | 49.151 ± 3.541 | 50.832 ± 4.725 | 52.627 ± 4.114 | 0.375 |
| Years after menopause | 6.562 ± 4.026 | 7.756 ± 5.424 | 6.724 ± 9.512 | 0.421 |
| BMD L2–L4 (g/cm2) | 0.986 ± 0.029 | 0.982 ± 0.035 | 1.101 ± 0.081 | 0.244 |
| BMD L2–L4 YA (%) | 82.142 ± 3.045 | 78.925 ± 2.904 | 91.091 ± 4.269 | 0.076 |
| BMD L2–L4 AM (%) | 89.071 ± 2.004 | 89.703 ± 3.018 | 97.601 ± 7.440 | 0.088 |
BMI body mass index, BMD L2–L4 YA bone mineral density in young adult, BMD L2–L4 AM bone mineral density compared with an age-matched, 6/6 the UGT1A1 promotor region contains six TA repeats, 7/7 the UGT1A1 promotor region contains seven TA repeats.