Table 4.
Characteristics of the postmenopausal women with osteopenia, osteoporosis and normal T-score taking part in the study of the rs4148323 genetic variant of UGT1A1 gene.
| Genotype | GG | GA | AA |
|---|---|---|---|
| Osteopenia | |||
| Mean ± SD n = 108 |
Mean ± SD n = 1 |
Mean ± SD n = 0 |
|
| Age (years) | 53.332 ± 8.17 | 52 | – |
| T-score | − 1.803 ± 0.439 | − 1.900 | – |
| Z-score | − 0.929 ± 0.112 | − 0.487 | – |
| Body mass (kg) | 65.338 ± 1.071 | 74.000 | – |
| BMI (kg/m2) | 24.647 ± 0.384 | 27.180 | – |
| Birthweight (g) | 3346.543 ± 100.622 | 3200.000 | – |
| Years of reproduction | 35.643 ± 4.043 | 36 | – |
| Age of first menstruation | 12.432 ± 4.321 | 11 | – |
| Age of last menstruation | 48.435 ± 4.133 | 47 | – |
| Years after menopause | 6.732 ± 4.221 | 5 | – |
| BMD L2–L4 (g/cm2) | 0.963 ± 0.022 | 0.964 | – |
| BMD L2–L4 YA (%) | 80.582 ± 1.932 | 80.000 | – |
| BMD L2–L4 AM (%) | 88.531 ± 2.014 | 95.000 | – |
| Osteoporosis | |||
|---|---|---|---|
| Mean ± SD n = 333 |
Mean ± SD n = 0 |
Mean ± SD n = 0 |
|
| Age (years) | 54.447 ± 4.17 | – | – |
| T-score | − 3.164 ± 0.056 | – | – |
| Z-score | − 3.569 ± 1.946 | – | – |
| Body mass (kg) | 61.208 ± 0.938 | – | – |
| BMI (kg/m2) | 23.787 ± 0.318 | – | – |
| Birth weight (g) | 3141.250 ± 134.079 | – | – |
| Years of reproduction | 35.993 ± 4.023 | – | – |
| Age of first menstruation | 13.092 ± 4.317 | – | – |
| Age of last menstruation | 48.981 ± 4.032 | – | – |
| Years after menopause | 8.572 ± 4.208 | – | – |
| BMD L2–L4 (g/cm2) | 0.975 ± 0.014 | – | – |
| BMD L2–L4 YA (%) | 81.278 ± 1.240 | – | – |
| BMD L2–L4 AM (%) | 89.504 ± 1.123 | – | - |
| Controls | |||
|---|---|---|---|
| Mean ± SD n = 231 |
Mean ± SD n = 2 |
Mean ± SD n = 0 |
|
| Age (years) | 53.617 ± 8.271 | 55.037 ± 2.831 | |
| T-score | 0.110 ± 0.120 | − 0.795 ± 0.095 | – |
| Z-score | 0.689 ± 0.205 | − 0.055 ± 0.475 | – |
| Body mass (kg) | 68.633 ± 1.571 | 74.052 ± 10.211 | – |
| BMI (kg/m2) | 26.031 ± 0.591 | 26.345 ± 1.65 | – |
| Birth weight (g) | 3630.556 ± 116.258 | 3652.500 ± 164.026 | – |
| Years of reproduction | 36.373 ± 5.523 | 37.563 ± 2.433 | – |
| Age of first menstruation | 13.522 ± 1.812 | 11.542 ± 0.717 | – |
| Age of last menstruation | 50.441 ± 4.332 | 49.000 ± 1.412 | – |
| Years after menopause | 7.112 ± 5.728 | 6.040 ± 1.412 | – |
| BMD L2–L4 (g/cm2) | 0.973 ± 0.023 | 0.955 ± 0.025 | – |
| BMD L2–L4 YA (%) | 81.333 ± 1.291 | 80.703 ± 1.104 | – |
| BMD L2–L4 AM (%) | 87.420 ± 2.072 | 88.325 ± 2.475 | – |
BMI body mass index, BMD L2–L4 YA bone mineral density in young adult, BMD L2–L4 AM bone mineral density compared with an age-matched.
The AA genotype for the rs4148323 variant in the UGT1A1 gene was not identified. The GA genotype for women with osteoporosis was also not identified.