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. 2021 Aug 30;11:17324. doi: 10.1038/s41598-021-96467-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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FAERS/AERS cohorts based on indications and treatments in efficacy trials for all ICIs. The two groups on each sub-cohort indicate the treatment vs control used in the efficacy trials. NSCLC non-small cell lung cancer, SCLC small cell lung cancer, RCC renal cell carcinoma, MCC Merkel cell carcinoma, CSCC cutaneous squamous cell carcinoma.