TABLE 1.
Demographic and Clinical Characteristics of Children and Adolescents Treated for Drug-Susceptible TB in the South African Reporting Cohort, by Vitality Status and Mortality, 2004–2016
| Variable | All Patients With TB in Reporting Cohort (N = 729 463), n | Patients With TB With Known Vitality Status (n = 612 655 [84.0%]), n (%) | Patients With TB Who Died (n = 18 539 [3.0%]), n (%) | CFRa (Patients With TB Who Died: 2.5%), % |
|---|---|---|---|---|
| Age, y | ||||
| 0–4 | 339 719 | 287 085 (84.51) | 7709 (2.69) | 2.26 |
| 5–9 | 134 616 | 115 156 (85.54) | 2776 (2.41) | 2.06 |
| 10–14 | 74 674 | 63 615 (85.19) | 2417 (3.80) | 3.23 |
| 15–19 | 180 454 | 146 799 (81.35) | 5637 (3.84) | 3.12 |
| Sex | ||||
| Male | 355 560 | 298 020 (83.82) | 8614 (2.89) | 2.42 |
| Female | 373 897 | 314 634 (84.15) | 9925 (3.15) | 2.65 |
| HIV status | ||||
| HIV-negative | 245 787 | 216 753 (88.19) | 2387 (1.10) | 0.97 |
| HIV-positive, on ART | 56 068 | 48 493 (86.49) | 2680 (5.53) | 4.77 |
| HIV-positive, no ART | 46 575 | 37 418 (80.34) | 2917 (7.80) | 6.26 |
| HIV status unknown | 381 033 | 309 991 (81.36) | 10 555 (3.40) | 2.77 |
| Previous TB history | ||||
| New | 691 834 | 584 350 (84.46) | 16 610 (2.84) | 2.40 |
| Retreatment | 37 628 | 28 305 (75.22) | 1929 (6.82) | 5.13 |
| Site of TB diseaseb | ||||
| Pulmonary TB | 664 041 | 561 255 (84.52) | 15 760 (2.81) | 2.37 |
| EPTB | 65 418 | 51 400 (78.57) | 2779 (5.41) | 4.25 |
| Disseminated diseasec | ||||
| Not disseminated | 640 136 | 541 006 (84.51) | 15 189 (2.81) | 2.37 |
| Disseminated | 12 245 | 9389 (76.68) | 882 (9.39) | 7.20 |
| Year | ||||
| 2004 | 53 081 | 40 389 (76.09) | 1505 (3.73) | 2.83 |
| 2005 | 55 426 | 44 096 (79.56) | 1670 (3.79) | 3.01 |
| 2006 | 60 482 | 49 638 (82.07) | 1842 (3.71) | 3.04 |
| 2007 | 62 981 | 52 069 (82.67) | 2101 (4.04) | 3.34 |
| 2008 | 68 106 | 56 206 (82.53) | 2072 (3.69) | 3.04 |
| 2009 | 69 559 | 58 800 (84.53) | 1930 (3.28) | 2.77 |
| 2010 | 64 003 | 53 342 (83.34) | 1674 (3.14) | 2.62 |
| 2011 | 63 887 | 55 268 (86.51) | 1364 (2.47) | 2.14 |
| 2012 | 55 002 | 48 037 (87.34) | 1127 (2.35) | 2.05 |
| 2013 | 51 572 | 45 454 (88.14) | 942 (2.07) | 1.82 |
| 2014 | 47 904 | 39 784 (83.05) | 878 (2.21) | 1.83 |
| 2015 | 42 986 | 38 635 (89.88) | 769 (1.99) | 1.79 |
| 2016 | 34 474 | 30 937 (89.74) | 665 (2.15) | 1.93 |
| Outcome 1 | ||||
| Cured or completed | 591 640 | 591 640 (100.00) | — | — |
| Died | 18 539 | 18 539 (100.00) | 18 539 (100.00) | — |
| Loss to follow-up | 116 808 | 0 (0.00) | — | — |
| Failed or drug resistant | 2476 | 2476 (100.00) | — | — |
—, not applicable.
a
CFR was calculated as a percentage by using the number of deaths over the total number of patients with TB.
b
The binary classification of site of disease included pulmonary TB, which was based on the presence of any pulmonary TB, and EPTB, which was restricted to exclusive EPTB.
c
Disseminated disease was based on ICD-10 coding, with neurologic TB and miliary TB recorded as disseminated disease and all other ICD-10 codes recorded as not disseminated.