TABLE 4.
Clinical and imaging measurements for COPD subtypes defined by computed tomography#
| ADE | Confluent | Moderate | Mild | Trace | p-value ¶ | |
| Subjects n (%) | 22 (30%) | 9 (12%) | 10 (14%) | 15 (20%) | 15 (20%) | |
| FEV1 L | 0.99±0.30 | 1.05±0.46 | 1.5±0.73 | 1.4±0.46 | 1.8±0.52 | <0.001 |
| FVC L | 3.1±0.78 | 3.1±0.70 | 3.0±1.2 | 2.7±0.75 | 3.1±0.74 | ns |
| Smoker % | 10 | 11 | 20 | 11 | 7 | |
| Smoking years | 42±6 | 44±13 | 39±12 | 35±11 | 35±13 | ns |
| 6MWD m | 343±104 | 335±145 | 375±98 | 377±81 | 478±115 | <0.05 |
| Perc15 HU | −949±41 | −918±18 | −890±35 | −865±24 | −833±32 | <0.001 |
| nKi ×10−3 mL·cm−3·min−1 | 4.0±1.1 | 4.0±1.1 | 3.9±1.1 | 3.5±1.1 | 3.5±0.9 | ns |
Data are presented as mean±sd, unless otherwise stated. ADE: advanced destructive emphysema; FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; 6MWD: 6-min walking distance; ns: nonsignificant. #: only centrilobular emphysema subtypes are analysed; n=74 high-resolution computed tomography COPD scans analysed, three (4%) scans were panlobular emphysema so were not included in analysis; no scans were identified as paraseptal emphysema, airway disease or associated features noted. ¶: overall comparison across five subtypes.