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. 2021 Jun 24;25:416–443. doi: 10.1016/j.omtn.2021.06.006

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© 2021 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Schematic representation of the structures of mitochondrial dynamics (MD) proteins (MDPs) and their roles in the mitochondrial dynamics pathway

(A and C) Structural features of mitochondrial fusion (A) and mitochondrial fission (C) proteins. (B and D) Summary of steps involved in the mitochondrial fusion (B) and fission (D) processes. TM, transmembrane; HR1, heptad repeat 1; HR2, heptad repeat 2; GED, GTPase effector domain; PR, proline rich; HS, hydrophobic segment; BSE, bundle signaling element; CC, coiled-coil; RR, repeat region; PH, pleckstrin homology; NTD, nucleotidyl transferase domain; TPR, tetratricopeptide repeat; WD, tryptophan (W) and aspartic acid (D).