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. 2021 Aug 13;297(3):101075. doi: 10.1016/j.jbc.2021.101075

Figure 4.

Figure 4

Stabilized SETD2 loses dependency on it activators for H3K36me3 deposition.A, western blotting of whole-cell extracts with the indicated antibodies. B, cartoon showing SETD2 truncations that were used in the experiments for the panels below. C, D, G and H, microscopy images and their quantification of cells expressing GFP-SETD2 constructs, and E and I, western blotting of whole-cell extracts with the indicated antibodies. The scale bar represents 1 mm. F, cartoon from http://www.cbioportal.org depicting the location of various mutations found in the SETD2 gene of patients with cancer that may result in the generation of truncated forms of SETD2 with altered half-lives.