Table 2.
Explant pathology findings according to groups at last evaluation in patients receiving locoregional therapies and reassessment before to liver transplantation.
| Variable at explant analysis | Categorisation at last evaluation |
p value | |||
|---|---|---|---|---|---|
| Within MC, n = 680 (77.0%) | Within UCSF-DS and downstaged to MC, n = 42 (4.8%) | AC and downstaged to MC, n = 21 (2.4%) | Not downstaged or progressed, n = 140 (15.9%) | ||
| Complete necrosis, n (%) | 23 (3.4) | 2 (4.8) | 0 | 5 (3.6) | 0.83 |
| MVI, n (%) | 142 (23.8) | 10 (23.8) | 11 (52.4) | 48 (34.3) | <0.0001 |
| Tumour grade >II, n (%) | 171 (26.4) | 17 (42.5) | 4 (20.0) | 40 (30.5) | 0.12 |
| Within MC, n (%) | 496 (72.9) | 23 (54.8) | 6 (28.6) | 50 (35.7) | <0.0001 |
AC indicates groups initially beyond the UCSF-DS and successfully downstaged to within MC. MC indicates group initially and remaining within MC between listing and last tumour reassessment. UCSF-DS indicates groups initially within the UCSF-DS and successfully downstaged to within MC. Categorical data were compared using Fisher’s exact test or Chi-square test (2-tailed), as appropriate. AC, all-comers; MC, Milan criteria; MVI, microvascular invasion; UCSF-DS: University of California San Francisco downstaging.