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METTL3 is upregulated in oxLDL-induced THP1 monocyte inflammation.A and B, THP-1 cells were treated with 20 μg/ml oxLDL for 0, 3, 6, 12, 24, and 48 h. A, immunoblot detection of METTL3 protein levels of untreated and oxLDL-treated cells, with GAPDH as a loading control (n = 3). B, qRT-PCR determination of mRNA levels of IL-1β, IL-6, TNF-α, and CXCL10 in response to oxLDL (n = 3). Data are represented as mean ± SD. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ∗∗∗∗p < 0.0001 in all figures.
