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. 2021 Aug 31;20:58. doi: 10.1186/s12941-021-00467-2

Table 2.

Demographic data of patients, phenotypic and molecular characteristics of the hvKp isolates included in this study

Hospital Ward Source String test Virulence factor genes Capsule serotype ompK36 typing Antibiotic resistance pattern Antibiotic resistance genes MIC (µg/ml)
CAZ IMI
A Internal Tracheal Neg iucA, iutA, ybt K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15 and blaOXA-48

ND

ND
A ICU Blood Neg iucA, iutA, ybt K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15 and blaOXA-48

ND

ND
A Emergency Urine Pos iucA, kfu, ybt ND B ND blaSHV

ND

ND
A ICU Tracheal Neg iucA K20 A CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaOXA-48 and blaNDM-1

ND

ND
A Surgery Abscess Pos iucA, ybt ND A CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

ND

ND
A Surgery Abscess Pos iucA ND C ND blaSHV

ND

ND
A Surgery Abdominal Secretions Pos peg-344, iucA, iutA, iro, ybt K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP blaSHV and blaCTX-M-15

16

< 2
A ICU Tracheal Neg iucA ND A CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaOXA-48 and blaNDM-1

ND

ND
A ICU Urine Pos iucA, kfu ND B Susceptible ND

ND

ND
A ICU Blood Neg iucA, ybt ND A CTX blaSHV

ND

ND
A ICU Synovial fluid Neg iucA, kfu ND B Susceptible ND

ND

ND
A Out-patient Urine Pos iucA, ybt ND C GN, CTX, CAZ blaTEM and blaSHV

ND

ND
A ICU Abscess Neg iucA, iutA K20 C CTX, GN, IMI, CRO, CAZ blaTEM

ND

ND
A Internal Urine Neg iucA ND A ND blaTEM and blaSHV

ND

ND
A ICU Urine Pos iucA, kfu, ybt K2 C CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15 and blaOXA-48

ND

ND
A Internal Urine Neg iucA, ybt ND D ND blaSHV, blaCTX-M-15 and blaOXA-48

ND

ND
A Out-patient Urine Pos iucA, ybt ND C Susceptible ND

ND

ND
A Internal Urine Pos iucA, kfu, ybt ND C ND blaSHV and blaCTX-M-15

ND

ND
A Out-patient Urine Neg iucA, iutA, ybt, rmpA ND C CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaTEM, blaCTX-M-15 and blaNDM-1

ND

ND
A Out-patient Urine Pos iucA, kfu ND A ND blaTEM, blaSHV and blaCTX-M-15

ND

ND
A Out-patient Urine Pos iucA, ybt K20 B ND blaSHV and blaCTX-M15

ND

ND
A Internal Urine Neg iucA, kfu ND C ND blaSHV

ND

ND
A Internal Sputum Pos peg-344, iucA, iutA, ybt, rmpA K20 C CTX, CAZ ND

ND

ND
A Surgery Abdominal Secretions Pos iucA ND A ND blaSHV, blaOXA-48 and blaNDM-1

ND

ND
A Emergency Urine Pos iucA, kfu, ybt K2 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15 and blaOXA-48

ND

ND
A Out-patient Urine Pos iucA, kfu, ybt K2 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15 and blaOXA-48

ND

ND
A Surgery Urine Pos iucA, kfu, ybt ND A CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

ND

ND
A Emergency Urine Pos iucA, kfu ND A ND blaSHV

ND

ND
A ICU Blood Pos iucA, kfu ND D CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaSHV, blaOXA-48 and blaNDM-1

ND

ND
A ICU Wound Neg iucA, ybt ND D Susceptible ND

ND

ND
A Graft Urine Neg iucA, kfu, rmpA K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP blaTEM, blaCTX-M-15 and blaOXA-48

ND

ND
A Out-patient Urine Pos iucA, kfu ND C CTX, GN, FEP, CRO, CAZ, CIP blaTEM, blaSHV and blaCTX-M15

ND

ND
A Graft Urine Neg iucA, ybt, allS, rmpA K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15, blaOXA-48, blaNDM-1

> 16

4
A ICU Abscess Neg iucA ND C Susceptible ND

ND

ND
A ICU Urine Neg iucA ND C CTX, FEP, CAZ blaSHV

ND

ND
A ICU Blood Neg iucA ND D ND blaCTX-M-15 and blaOXA-48

ND

ND
A ICU Abscess Pos iucA, iutA, ybt, rmpA K20 C ND blaTEM, blaCTX-M15 and blaNDM-1

64

> 4
A Internal Tracheal Neg iucA, ybt ND A CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaSHV, blaCTX-M-15 and blaOXA-48

ND

ND
A ICU Tracheal Neg iucA, iutA ND C CTX, GN, FEP, CRO, AK, CAZ blaSHV

ND

ND
A Surgery Wound Neg iucA, kfu, ybt ND C CTX, CRO, CIP blaSHV

ND

ND
A Internal Abscess Neg iucA, ybt ND D CTX, GN, IMI, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15 and blaOXA-48

ND

ND
A Surgery Abscess Neg iucA, ybt ND C CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaTEM, blaCTX-M-15 and blaOXA-48

ND

ND
A Emergency Urine Neg iucA, kfu, ybt ND C Susceptible ND

ND

ND
A Internal Sputum Pos iucA, iutA, ybt K20 C CTX, GN, FEP, CRO, CAZ blaTEM, blaSHV and blaCTX-M-15

ND

ND
A Out-patient Urine Neg iucA, kfu, ybt ND A CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP blaCTX-M-15 and blaOXA-48

ND

ND
A ICU Abscess Pos iucA, ybt ND D CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

> 16

8
A Emergency Blood Neg iucA, kfu ND B AK ND

ND

ND
A ICU Tracheal Neg iucA, ybt ND A CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaCTX-M-15 and blaOXA-48

ND

ND
A ICU Blood Pos iucA, ybt ND D CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaSHV, blaCTX-M-15 and blaOXA-48

ND

ND
A Neurology Urine Pos iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15 and blaOXA-48

ND

ND
A Emergency Urine Pos iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15 and blaOXA-48

ND

ND
A Internal Wound Pos iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15 and blaOXA-48

16

2
A Emergency Urine Pos iucA, iutA, ybt, rmpA ND C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15 and blaOXA-48

32

> 4
A ICU BAL Pos iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15 and blaOXA-48

ND

ND
A Surgery Urine Pos iucA, iutA, ybt, rmpA K20 C CTX, GN, FEP, CRO, CAZ, CIP, MRP blaTEM, blaSHV and blaCTX-M15

ND

ND
A ICU Blood Pos iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaTEM, blaSHV and blaCTX-M15

> 16

> 4
A Internal Urine Pos iucA, iutA, ybt, rmpA K20 C CTX, GN, FEP, CRO, CAZ, CIP blaTEM, blaSHV and blaCTX-M-15

ND

ND
A ICU Tracheal Pos iucA, iutA, rmpA ND C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15 and blaOXA-48

ND

ND
A ICU BAL Pos iucA, iutA, ybt, rmpA K20 D CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaCTX-M-15 and blaOXA-48

64

> 4
A Emergency Urine Pos iucA, iutA, ybt K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP blaTEM and blaCTX-M15

ND

ND
A ICU CSF Pos iucA, iutA, ybt, rmpA K20 C CTX, GN, FEP, CRO, CAZ, CIP blaTEM, blaSHV and blaCTX-M-15

ND

ND
A ICU Tracheal Pos iucA, ybt K20 D CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15 and blaOXA-48

ND

ND
A ICU Blood Pos iucA, iutA, ybt, rmpA K20 C CTX, FEP, CRO, CAZ, CIP blaTEM, blaSHV and blaCTX-M-15

ND

ND
B Infectious Sputum Neg IutA, ybt ND C CTX, GN, FEP, CRO, CAZ, CIP blaCTX-M-15

ND

ND
B Infectious Sputum Pos iucA, ybt ND D CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15 and blaOXA-48

64

8
B ICU Urine Neg iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

64

16
B Infectious Urine Neg iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

> 16

> 4
B ICU Tracheal Neg iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

64

4
B ICU Tracheal Pos iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15 and blaOXA-48

64

> 4
B ICU Urine Neg iucA, iutA, ybt, rmpA K20 C CTX, GN, FEP, CRO, CAZ, CIP, AZM blaTEM, blaSHV and blaCTX-M-15

ND

< 2
B ICU Tracheal Neg iucA, kfu, ybt K20 C CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15 and blaNDM-1

> 16

> 4
B ICU Tracheal Neg iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

64

4
B Surgery Wound Neg iucA, iutA, ybt, rmpA K20 C CTX, FEP, CRO, AK, CAZ, CIP blaTEM, blaSHV and blaCTX-M-15

ND

ND
B ICU Blood Pos peg-344, IucA, iutA, iro, kfu, ybt, magA, allS K1 C CTX, FEP, CRO, CAZ, CIP blaTEM, blaSHV and blaCTX-M-15

> 16

< 2
B ICU Tracheal Neg iucA, ybt, rmpA K20 C CTX, FEP, CRO, CAZ, CIP blaTEM, blaSHV, blaCTX-M-15

ND

2
B ICU Tracheal Neg iucA, iutA, ybt, rmpA K20 C CTX, FEP, CRO, CAZ, CIP blaTEM, blaSHV and blaCTX-M-15

ND

2
B ICU Urine Neg iucA, iutA, ybt, rmpA K20 C CTX, FEP, CRO, CAZ, CIP blaTEM, blaSHV, blaCTX-M-15

ND

2
B Surgery Urine Pos iucA, iutA, ybt, rmpA K20 C CTX, FEP, CRO, CAZ, CIP blaTEM, blaSHV and blaCTX-M-15

ND

ND
B ICU Tracheal Pos iutA, iro, rmpA ND C CTX, GN, FEP, CRO, AK, CAZ, CIP blaCTX-M-15

ND

ND
B ICU Tracheal Neg iutA ND C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP blaTEM and blaSHV

ND

ND
B Internal Urine Pos iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP blaTEM, blaSHV, blaCTX-M-15 and blaOXA-48

ND

4
B Internal Tracheal Pos iucA, iutA, kfu, ybt, rmpA K20 D CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP blaTEM, blaSHV, blaCTX-M-15 and blaOXA-48

ND

> 4
B Emergency Urine Pos iucA, iutA, kfu, ybt, rmpA K20 C CTX, FEP, CRO, AK, CAZ, CIP blaSHV and blaCTX-M-15

ND

ND
B Surgery Tracheal Neg iucA, iutA, ybt, rmpA K20 C CTX, GN, FEP, CRO, CAZ, CIP blaSHV and blaCTX-M-15

ND

ND
B ICU Tracheal Pos iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M15, blaOXA-48 and blaNDM-1

32

> 4
B Infectious Tracheal Neg iutA, ybt ND A CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

64

> 4
B ICU Tracheal Neg iucA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

32

4
B ICU Tracheal Neg iutA K20 A CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15 and blaNDM-1

ND

> 4
B ICU Tracheal Neg iucA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

64

> 4
B ICU Tracheal Neg iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

ND

< 1
B ICU Tracheal Neg iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

ND

16
B ICU CSF Neg iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

128

> 4
B ICU Urine Neg iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

64

< 4
B ICU BAL Pos iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

ND

4
B ICU Tracheal Neg iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

64

> 4
B ICU Tracheal Pos iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

ND

> 4
B Surgery Blood Neg iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

ND

256
B ICU Tracheal Neg iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

ND

16
B Surgery Wound Neg iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

ND

ND
B ICU Tracheal Pos iucA, iutA, iro, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, AK, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

ND

8
B ICU Tracheal Neg iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaTEM, blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

ND

8
B ICU Tracheal Neg iucA, iutA, ybt, rmpA K20 C CTX, GN, IMI, FEP, CRO, CAZ, CIP, MRP, AZM blaSHV, blaCTX-M-15, blaOXA-48 and blaNDM-1

ND

8

*M, male; F, female; ICU, Intensive Care Unit; BAL, bronchoalveolar lavage; CSF, cerebrospinal fluid; Pos, positive; Neg, negative; iucA and iutA, aerobactin genes; ybt, yersiniabactin; rmpA, regulator of mucoid phenotype; Kfu, Klebsiella iron uptake; magA, mucoviscosity-associated gene; iroB, salmochelin iron uptake systems; allS, allantoin metabolism gene; peg-344, metabolic transporter; AK, amikacin; GN, gentamicin; CTX, cefotaxime; CAZ, ceftazidime; CRO, ceftriaxone; IMI, imipenem; MRP, meropenem; FEP, cefepime; CIP, ciprofloxacin;; AZM, aztreonam; MIC, minimum inhibitory concentration; ND, not determined