Fig. 1.

Diagram of analysis steps. Conceptual depiction of analysis steps including: (1) a unique pair of one UD and one HC participant is held-out; (2) an elastic net regression is used to select variables; (3) the retained variables are used an LDA model predicting case/control status; (4) the LDA model is tested on the held-out sample; (5) this process is repeated for each of the n = 1833 pairs of subjects; (6) for each held-out pair, the training procedure is repeated with 100 unique permutations.