Fig. 7.

CK2 inhibition by silmitasertib attenuates CCL7 expression and macrophage infiltration. (A-F) C57/BL6 mice were injected with LPS in the presence or absence of silmitasertib. Scheme of protocol (A). Plasma ALT (B) and AST (C) levels were examined by colorimetric kits. Macrophages were stained with anti-CD68 (D). CCL7 expression was examined by qPCR (E) and ELISA (F). (G-L) C57/BL6 mice were fed the MCD diet in the presence or absence of silmitasertib. Scheme of protocol (G). Plasma ALT (H) and AST (I) levels were examined by colorimetric kits. Macrophages were stained with anti-CD68 (J). CCL7 expression was examined by qPCR (K) and ELISA (L). Scale bar, 50 μm.