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. 2021 Apr 29;56(5):581–588. doi: 10.1093/alcalc/agab034

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© The Author(s) 2021. Medical Council on Alcohol and Oxford University Press. All rights reserved.

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Fig. 2. — CeA GABAergic transmission postsynaptic kinetics are estrous cycle dependent and affected by alcohol dependence. There are no significant differences in naïve and dependent female baseline sIPSC frequency (A), amplitude (B) or decay time (D) regardless of estrous cycle. (C) Female CeA baseline sIPSC rise time is dependent on estrous cycle and alcohol dependence. Estrus naïve female CeA sIPSC rise time (2.55 ± 0.09 ms) is significantly slower than proestrus (2.14 ± 0.08 ms) or metestrus/diestrus (2.12 ± 0.08 ms) naïve females. Alcohol dependence induces a slower sIPSC rise time in metestrus/diestrus females (2.68 ± 0.07 ms) compared with naïve females in the same stage of the estrous cycle. n = 3–32 neurons per group. ^*Significant difference (P < 0.05).