Table 2.
Association of serum phosphorus levels with the composite kidney disease progression outcome
| Groups |
|
|||
|---|---|---|---|---|
| Unadjusted | Model 1 | Model 2 | Model 3 | |
| Composite kidney disease progression outcome according to the level of serum phosphorus, HR (95% CI) | 3.67 (2.04–6.63) | 4.51 (2.45–8.28) | 2.58 (1.17–5.68) | 3.54 (1.37–9.12) |
| P-value | <0.001 | <0.001 | 0.02 | 0.009 |
| Phosphorus quartiles (mmol/L, range), HR (95% CI) | ||||
| First (0.35 − 1.07) | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| Second (1.08–1.19) | 1.66 (1.14–2.44) | 1.72 (1.17–2.53) | 1.57 (0.95–2.57) | 1.66 (0.91–3.01) |
| P-value | 0.009 | 0.006 | 0.08 | 0.098 |
| Third (1.20–1.32 | 1.54 (1.04–2.27) | 1.70 (1.15–2.52) | 1.48 (0.90–2.43) | 1.67 (0.91–3.08) |
| P-value | 0.03 | 0.009 | 0.13 | 0.10 |
| Fourth (1.33–2.24) | 1.94 (1.33–2.83) | 2.18 (1.48–3.19) | 1.95 (1.20–3.16) | 2.62 (1.44–4.77) |
| P-value | 0.001 | <0.001 | 0.001 | <0.002 |
| P-value for trend | 0.002 | <0.001 | 0.01 | 0.002 |
CKD progression events were a 50% decrease in the eGFR or kidney failure. Model 1 was adjusted for sex and age, and sex was expressed as a dichotomous variable. Model 3 was adjusted for covariates in Model 2 and Oxford classification (MEST-C scores)