FIG 1.

Personalizing delivery of gene-encoded antibodies against antimicrobial-resistant pathogens. (A) Overview of priority bacterial and fungal pathogens and risk factors of concern for AMR (CDC and WHO). (B) Personalizing therapeutic protection against resistant bacteria. Following specimen collection, bacteria are cultured and typed for identification and characterization. A preidentified panel of gene-encoded antibodies can be delivered to the patient as an off-the-shelf intervention. Gene-encoded MAbs enter cells and express and secrete functional antibodies that lead to pathogen elimination. (C) Personalizing preventative protection against resistant bacteria. The preidentified panel of gene-encoded antibodies is delivered in advance of a surgical intervention, chronic disease, or at-risk behavior. The gene-encoded MAbs enter cells and express and secrete functional antibodies that prevent infection. (D) Gene-encoded MAbs may be delivered alone or in conjunction with the antibiotic standard of care or recombinant antibodies.