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. 2021 Jul 20;12(4):e01188-21. doi: 10.1128/mBio.01188-21

TABLE 3.

Impact of independent, double and triple mutations in the spike protein

Protein Combinations Mutations ΔΔG (pred) C (pred)
Spike Independent D614G 0.422 0.892
Double D614G+S477N 0.228 0.896
D614G+A222V 0.195 0.889
Triple D614G+S477N+A222V 0.129 0.129