TABLE 1.
List of genes significantly upregulated or downregulated in the three knockout mouse lines relative to WT micea
| CD28−/− | CD28−/− CTLA4−/− | PDL1−/− | ||
|---|---|---|---|---|
| Ccl4 | Nod1 | Tlr9 | Tlr13 | Vsir |
| Lif | Icos | Was | Icosl | Furin |
| Nr4a2 | Amica1 | Il15 | Top2a | Adgre1 |
| Klf10 | Ldlr | Arg1 | Fgf18* | Ifnar2 |
| Hip1r* | Gata2 | Nlrp3 | Rab20 | Skil |
| Akap13* | Btg2 | Alox5 | Gpr65 | Fscn1 |
| Mertk* | Nectin2 | Adcyap1r1 | Adam19* | C3ar1 |
| Gpr183* | Ccr9 | Btla | Cytip | Adamts1 |
| Lta4h* | Flt1 | Rgs1 | Gadd45b | Cxcl16 |
| F11r* | Nfkbie | Cd80 | Irf8 | Cybb |
| Vav2* | Abcf1 | Ms4a1 | Vav1 | Ptprc |
| Fadd* | Dusp2 | Ccl3 | Tlr8 | Lipa |
| Id1* | Cdh1 | Klk1 | Alox5ap | Cxcl14 |
| Id3* | Il4ra | Mmp19 | Itgam | Anxa4 |
| Stat4* | Fgfr1 | Lst1 | Cd180 | Grn |
| Apoe* | Traf6 | Cdh4* | Plau | Cxcl9 |
| H2-Ab1* | Acly | Ccl19 | Cd38 | Cd68 |
| Cd74* | Foxp3 | Siglec1 | Trafd1 | Laptm5 |
| Ltb* | Timp3 | Plaur | Tnfaip8 | Rhog |
| Cxcr6* | Calr | Mapk12* | Cxcl11 | Insig1* |
| H2-Q2* | Map2k1 | Csf2ra | BclII* | Tspan8* |
| Cd8* | Stat6 | Tnfrsf1b | Itgb2 | Sirpa |
| Glg1 | Sema4a | Tlr4 | Prkca* | |
| Mapk14 | Gem | Clec7a | Nmb* | |
| Map2k2 | Fpr2 | Tnfrsf12a | Sesn1* | |
| Tfcp2 | Tlr2 | Nfkb1 | Tyrobp | |
| Lag3 | Pik3cg | Cd84 | Prdx3 | |
| Gnai3 | Btk | Selplg | Id2 | |
| Coasy | Adam8 | Pdgfra | Serpinb6a* | |
| Msh2 | Mmp12 | Trem2 | Ctss | |
| Vegfc* | Lat2 | Anxa1 | Psme2 | |
| Il9* | Ptafr | Il1rap | C1qc | |
| Cldn1* | Tlr3 | Fcgr3 | Cstb | |
| Ngf* | Hpgds | Cd274 | Tuba4a* | |
| Ptgds* | Cd86 | Rin2 | Sptbn1* | |
| Cx3cr1* | Csf3r | Pros1 | H2-D1 | |
| Siglecf* | Syk | Mafb | H2-K1 | |
| Cxcr4 | Marcksl1 | |||
a
Upregulated genes are shown with asterisk.