TABLE 2.

List of 27 common downregulated genes in the three knockout mouse lines relative to WT mice^a

Gene designation	Level of downregulation by mouse strain
	CD28−/−	CD28−/− CTLA4−/−	PDL1−/−
Ccl12	−3.76	−3.34	−4.22
Ccl2	−4.13	−5.33	−8.05
Ccl7	−4.65	−5.61	−7.09
Ccrl2	−1.41	−1.82	−2.95
Cd25	−1.71	−3.20	−3.19
Cd40	−2.01	−4.93	−4.10
Cebpb	−1.41	−1.58	−1.87
Clic4	−1.49	−1.75	−1.98
Cxcl1	−1.98	−2.88	−2.88
Cxcl10	−6.76	−11.73	−9.85
Daxx	−2.49	−3.04	−2.73
Fcgr1	−1.94	−2.20	−3.34
Fcgr4	−1.62	−1.51	−2.35
ICP22 (HSV-1)	−3.07	−3.07	−3.07
Ifit1bl1	−4.06	−4.91	−5.85
Il1β	−1.86	−3.26	−2.48
Il1rn	−4.63	−7.98	−8.89
Irf2	−1.28	−1.42	−1.60
Irf7	−4.79	−9.14	−10.46
Isg15	−5.24	−5.46	−6.44
Mx1	−2.69	−3.11	−3.04
Mx2	−4.30	−5.00	−4.89
Nampt	−1.32	−1.52	−2.04
Socs1	−2.65	−3.91	−3.88
Socs3	−1.78	−2.66	−2.16
Tnfaip3	−1.29	−1.77	−2.38
Usp18	−4.09	−5.44	−6.05

^aMean for each gene was normalized to the mean of WT infected mice. n = 3.