FIG 3.
Virus titers were comparable in the respiratory system of SARS-CoV-2-infected male and female hamsters. Adult (8 to 10 weeks) male and female golden Syrian hamsters were infected with 105 TCID50 of SARS-CoV-2. Infectious virus titers in the homogenates of nasal turbinates (A), trachea (B), and lungs (C), were determined by TCID50 assay on 2, 4, and 7 dpi. Likewise, virus RNA copies in 100 ng of total RNA were assessed in the lungs of infected hamsters at 2, 4, 7, 14 and 28 dpi (D). Data are represented as mean ± standard error of the mean from one or two experiment(s) (n = 3 to 5/group) and were analyzed by two-way ANOVA (mixed-effects analysis) followed by Bonferroni’s multiple-comparison test. LOD, limit of detection.