TABLE 2.
Disease incidence in FVB/NJ mice, with and without UVB and DMBA treatment
| Group | Total no. of mice | Sexb | Nondysplastic (n) | LSIL (n) | HSIL (n) | SCC grade 1 (n) | SCC grade 2 (n) |
|---|---|---|---|---|---|---|---|
| Mock | 5 | 4 M, 1 F | 4 | 1 | |||
| Mock + UVB | 11 | 7 M, 4 F | 11 | ||||
| Mock + DMBA | 4 | 0 M, 4 F | 2 | 1 | 1 | ||
| Mock + UVB + DMBA | 16 | 9 M, 7 F | 11 | 3 | 1 | 1 | |
| MmuPV1 | 13 | 7 M, 6 F | 8 | 4 | 1 | ||
| MmuPV1 + UVB | 13 | 0 M, 13 F | 10 | 3 | |||
| MmuPV1 + DMBA | 7 | 5 M, 2 F | 4 | 3 | |||
| MmuPV1+ UVB +DMBAa | 15 | 3 M, 12 F | 2 | 7 | 2 | 3 | 1 |
a
Among MmuPV1+UVB+DMBA mice, the three males were graded as LSIL, HSIL, and SCC grade 2, and there was not a significant difference between males and females in disease severity (P = 0.28).
b
M, male; F, female.