. 2021 Aug 3;12(4):e01167-21. doi: 10.1128/mBio.01167-21

TABLE 1.

Percent amino acid identity of vhp in 30 clinical S. aureus isolates

Strain name	ST^a	vhp isoforms^b	Protein ID^c	CAI80 435.1^d	ANI73 772.1^d	AGO2 9166.1^d	ADL2 2693.1^d	CCG1 5434.1^d	ADI97 346.1^d	BAB9 4633.1^d	AGU6 0934.1^d	AMV8 4570.1^d	BAB4 1978.1^d	BAF7 7693.1^d	ABR5 1687.1^d	ADC3 6980.1^d	AQD1 8902.1^d	CCJ10 585.1^d	CAG3 9854.1^d	ADQ7 7850.1^d	AIO20 462.1^d	CRL3 3498.1^d	AFH6 9102.1^d	ABD2 9944.1^d	AEW6 4856.1^d	ABD2 1761.1^d	AAW3 6414.1^d	ELP41 198.1^d	EJE56 573.1^d	CBI48 744.1^d	AEV7 7849.1^d	ALQ9 9050.1^d	AGU5 4604.1^d
RF122	151	vhpA'	CAI80435.1	100^e	96.45^e	83.43^e	85.8^e	84.02^e	86.39^e	84.62^e	86.39^e	86.39^e	86.98^e	86.98^e	86.98^e	86.98^e	86.98^e	85.8^e	56.96	56.96	56.96	61.39	60.9	78.21	78.21	78.21	78.21	78.21	76.87	78.21	77.56	77.56	67.86
08-02300	7	vhpA'	ANI73772.1	96.45^e	100^e	83.43^e	84.62^e	84.02^e	86.39^e	84.62^e	86.39^e	86.39^e	88.17^e	88.17^e	88.17^e	88.17^e	88.17^e	86.98^e	55.7	55.7	55.7	60.13	59.62	75.64	75.64	75.64	75.64	75.64	74.15	75.64	75	75	66.07
CA-347	45	vhpA	AGO29166.1	83.43^e	83.43^e	100^e	93.64^e	93.06^e	93.64^e	94.8^e	94.22^e	94.22^e	93.64^e	93.64^e	93.64^e	93.64^e	93.64^e	92.49^e	70.37	70.37	70.37	73.46	70.62	63.46	63.46	63.46	63.46	63.46	61.22	63.46	62.82	62.82	66.07
JKD61 59	93	vhpA	ADL22693.1	85.8^e	84.62^e	93.64^e	100^e	92.49^e	94.8^e	95.38^e	94.8^e	94.8^e	95.38^e	95.38^e	95.38^e	95.38^e	95.38^e	94.22^e	69.14	69.14	69.14	72.84	70.62	63.46	63.46	63.46	63.46	63.46	61.22	63.46	62.82	62.82	66.96
HO 5096 0412	22	vhpA	CCG15434.1	84.02^e	84.02^e	93.06^e	92.49^e	100^e	95.95^e	94.8^e	96.53^e	96.53^e	95.95^e	95.95^e	95.95^e	95.95^e	95.95^e	94.8^e	69.75	69.75	69.75	72.22	74.38	64.1	64.1	64.1	64.1	64.1	61.9	64.1	63.46	63.46	65.18
ED133	133	vhpA	ADI97346.1	86.39^e	86.39^e	93.64^e	94.8^e	95.95^e	100^e	95.95^e	97.69^e	97.69^e	98.27^e	98.27^e	98.27^e	98.27^e	98.27^e	97.11^e	69.14	69.14	69.14	74.07	73.75	66.03	66.03	66.03	66.03	66.03	63.95	66.03	65.38	65.38	67.86
MW2	1	vhpA	BAB94633.1	84.62^e	84.62^e	94.8^e	95.38^e	94.8^e	95.95^e	100^e	98.27^e	98.27^e	96.53^e	96.53^e	96.53^e	96.53^e	96.53^e	95.38^e	69.14	69.14	69.14	74.69	72.5	64.1	64.1	64.1	64.1	64.1	61.9	64.1	63.46	63.46	66.96
CN1	72	vhpA	AGU60934.1	86.39^e	86.39^e	94.22^e	94.8^e	96.53^e	97.69^e	98.27^e	100^e	100^e	98.27^e	98.27^e	98.27^e	98.27^e	98.27^e	97.11^e	69.14	69.14	69.14	74.07	73.75	66.03	66.03	66.03	66.03	66.03	63.95	66.03	65.38	65.38	67.86
ST201 30943	25	vhpA	AMV84570.1	86.39^e	86.39^e	94.22^e	94.8^e	96.53^e	97.69^e	98.27^e	100^e	100^e	98.27^e	98.27^e	98.27^e	98.27^e	98.27^e	97.11^e	69.14	69.14	69.14	74.07	73.75	66.03	66.03	66.03	66.03	66.03	63.95	66.03	65.38	65.38	67.86
N315^f	5	vhpA	BAB41978.1	86.98^e	88.17^e	93.64^e	95.38^e	95.95^e	98.27^e	96.53^e	98.27^e	98.27^e	100^e	100^e	100^e	100^e	100^e	98.84^e	68.52	68.52	68.52	73.46	73.12	65.38	65.38	65.38	65.38	65.38	63.27	65.38	64.74	64.74	66.96
Mu3	5	vhpA	BAF77693.1	86.98^e	88.17^e	93.64^e	95.38^e	95.95^e	98.27^e	96.53^e	98.27^e	98.27^e	100^e	100^e	100^e	100^e	100^e	98.84^e	68.52	68.52	68.52	73.46	73.12	65.38	65.38	65.38	65.38	65.38	63.27	65.38	64.74	64.74	66.96
JH1	105	vhpA	ABR51687.1	86.98^e	88.17^e	93.64^e	95.38^e	95.95^e	98.27^e	96.53^e	98.27^e	98.27^e	100^e	100^e	100^e	100^e	100^e	98.84^e	68.52	68.52	68.52	73.46	73.12	65.38	65.38	65.38	65.38	65.38	63.27	65.38	64.74	64.74	66.96
04-02981	225	vhpA	ADC36980.1	86.98^e	88.17^e	93.64^e	95.38^e	95.95^e	98.27^e	96.53^e	98.27^e	98.27^e	100^e	100^e	100^e	100^e	100^e	98.84^e	68.52	68.52	68.52	73.46	73.12	65.38	65.38	65.38	65.38	65.38	63.27	65.38	64.74	64.74	66.96
ST88	88	vhpA	AQD18902.1	86.98^e	88.17^e	93.64^e	95.38^e	95.95^e	98.27^e	96.53^e	98.27^e	98.27^e	100^e	100^e	100^e	100^e	100^e	98.84^e	68.52	68.52	68.52	73.46	73.12	65.38	65.38	65.38	65.38	65.38	63.27	65.38	64.74	64.74	66.96
ST228	228	vhpA	CCJ10585.1	85.8^e	86.98^e	92.49^e	94.22^e	94.8^e	97.11^e	95.38^e	97.11^e	97.11^e	98.84^e	98.84^e	98.84^e	98.84^e	98.84^e	100^e	67.9	67.9	67.9	72.22	71.88	64.1	64.1	64.1	64.1	64.1	61.9	64.1	63.46	63.46	65.18
MRSA 252	36	vhpC	CAG39854.1	56.96	55.7	70.37	69.14	69.75	69.14	69.14	69.14	69.14	68.52	68.52	68.52	68.52	68.52	67.9	100^h	100^h	100^h	90.81^h	83.12	66.67	66.67	66.67	66.67	66.67	64.63	66.67	64.74	64.74	68.75
TCH60^g	30	vhpC	ADQ77850.1	56.96	55.7	70.37	69.14	69.75	69.14	69.14	69.14	69.14	68.52	68.52	68.52	68.52	68.52	67.9	100^h	100^h	100^h	90.81^h	83.12	66.67	66.67	66.67	66.67	66.67	64.63	66.67	64.74	64.74	68.75
ATCC 25923	243	vhpC	AIO20462.1	56.96	55.7	70.37	69.14	69.75	69.14	69.14	69.14	69.14	68.52	68.52	68.52	68.52	68.52	67.9	100^h	100^h	100^h	90.81^h	83.12	66.67	66.67	66.67	66.67	66.67	64.63	66.67	64.74	64.74	68.75
BB155	152	vhpC'	CRL33498.1	61.39	60.13	73.46	72.84	72.22	74.07	74.69	74.07	74.07	73.46	73.46	73.46	73.46	73.46	72.22	90.81^h	90.81^h	90.81^h	100^h	77.5	71.79	71.79	71.79	71.79	71.79	70.07	71.79	69.87	69.87	75.89
71193	398	vhpB'	AFH69102.1	60.9	59.62	70.62	70.62	74.38	73.75	72.5	73.75	73.75	73.12	73.12	73.12	73.12	73.12	71.88	83.12	83.12	83.12	77.5	100ⁱ	79.49ⁱ	79.49ⁱ	79.49ⁱ	79.49ⁱ	79.49ⁱ	78.91ⁱ	79.49ⁱ	78.21ⁱ	78.21ⁱ	85.71ⁱ
NTCT 8325	8	vhpB	ABD29944.1	78.21	75.64	63.46	63.46	64.1	66.03	64.1	66.03	66.03	65.38	65.38	65.38	65.38	65.38	64.1	66.67	66.67	66.67	71.79	79.49ⁱ	100^j	100^j	100^j	100^j	100^j	100^j	100^j	97.44^j	97.44^j	95.54^j
11819-97	80	vhpB	AEW64856.1	78.21	75.64	63.46	63.46	64.1	66.03	64.1	66.03	66.03	65.38	65.38	65.38	65.38	65.38	64.1	66.67	66.67	66.67	71.79	79.49ⁱ	100^j	100^j	100^j	100^j	100^j	100^j	100^j	97.44^j	97.44^j	95.54^j
USA300_FP R3757^k	8	vhpB	ABD21761.1	78.21	75.64	63.46	63.46	64.1	66.03	64.1	66.03	66.03	65.38	65.38	65.38	65.38	65.38	64.1	66.67	66.67	66.67	71.79	79.49ⁱ	100^j	100^j	100^j	100^j	100^j	100^j	100^j	97.44^j	97.44^j	95.54^j
COL	250	vhpB	AAW36414.1	78.21	75.64	63.46	63.46	64.1	66.03	64.1	66.03	66.03	65.38	65.38	65.38	65.38	65.38	64.1	66.67	66.67	66.67	71.79	79.49ⁱ	100^j	100^j	100^j	100^j	100^j	100^j	100^j	97.44^j	97.44^j	95.54^j
21282	254	vhpB	ELP41198.1	78.21	75.64	63.46	63.46	64.1	66.03	64.1	66.03	66.03	65.38	65.38	65.38	65.38	65.38	64.1	66.67	66.67	66.67	71.79	79.49ⁱ	100^j	100^j	100^j	100^j	100^j	100^j	100^j	97.44^j	97.44^j	95.54^j
Newbould 305	115	vhpB	EJE56573.1	76.87	74.15	61.22	61.22	61.9	63.95	61.9	63.95	63.95	63.27	63.27	63.27	63.27	63.27	61.9	64.63	64.63	64.63	70.07	78.91ⁱ	100^j	100^j	100^j	100^j	100^j	100^j	100^j	97.28^j	97.28^j	95.15^j
TW20	239	vhpB	CBI48744.1	78.21	75.64	63.46	63.46	64.1	66.03	64.1	66.03	66.03	65.38	65.38	65.38	65.38	65.38	64.1	66.67	66.67	66.67	71.79	79.49ⁱ	100^j	100^j	100^j	100^j	100^j	100^j	100^j	97.44^j	97.44^j	95.54^j
M013	59	vhpB	AEV77849.1	77.56	75	62.82	62.82	63.46	65.38	63.46	65.38	65.38	64.74	64.74	64.74	64.74	64.74	63.46	64.74	64.74	64.74	69.87	78.21ⁱ	97.44^j	97.44^j	97.44^j	97.44^j	97.44^j	97.28^j	97.44^j	100^j	100^j	99.11^j
MS4	338	vhpB	ALQ99050.1	77.56	75	62.82	62.82	63.46	65.38	63.46	65.38	65.38	64.74	64.74	64.74	64.74	64.74	63.46	64.74	64.74	64.74	69.87	78.21ⁱ	97.44^j	97.44^j	97.44^j	97.44^j	97.44^j	97.28^j	97.44^j	100^j	100^j	99.11^j
6850	50	vhpB	AGU54604.1	67.86	66.07	66.07	66.96	65.18	67.86	66.96	67.86	67.86	66.96	66.96	66.96	66.96	66.96	65.18	68.75	68.75	68.75	75.89	85.71ⁱ	95.54^j	95.54^j	95.54^j	95.54^j	95.54^j	95.15^j	95.54^j	99.11^j	99.11^j	100^j

ST, sequence type.

vhp isoforms indicate names of the isoforms.

Protein ID is the accession number of the vhp isoforms.

Percent identities of the vhp isoforms.

vhpA isotype groups.

Prototype for vhpA isotype group.

Prototype for vhpC isotype group.

vhpC isotype groups.

ⁱ

Hybrid vhpB' isotype groups.

vhpB isotype groups.

Prototype for vhpB isotype group.