TABLE 1.

MIC values for NIH clinical collection and Pathogen Box compounds against A. fumigatus

Compound	MIC (μM)	Description	Mode of action	Reference
Econazole nitrate	12.5	Broad-spectrum antimycotic agent	Inhibits ergosterol biosynthesis	120
Fluvastatin	25	Statin drug class used for hypercholesterolemia treatment; demonstrated antifungal activity against some fungal species	Blocks ergosterol biosynthesis by inhibition of farnesyl pyrophosphate production	121
Mesoridazine	3.12	Piperidine neuroleptic drug used for the treatment of schizophrenia, organic brain disorders, alcoholism, and psychoneuroses	Acts indirectly on reticular formation, whereby neuronal activity into reticular formation is reduced without affecting its intrinsic ability to activate the cerebral cortex	122
Cisapride	1.56	Gastroprokinetic agent, increases motility in the upper gastrointestinal tract	Parasympathomimetic acting as a serotonin 5-HT4 agonist	123
Oxiconazole nitrate	25	Salt form of oxiconazole with antifungal activity	Inhibits ergosterol biosynthesis	124
Indinavir sulphate	6.25	Antiretroviral protease inhibitor used in the therapy and prevention of HIV infection and AIDS	Protease inhibitor	125
Enalaprilat	25	Used in the treatment of hypertension	Angiotensin-converting enzyme inhibitor	126
Vincristine sulfate	25	Used in cancer chemotherapy	Inhibits microtubule formation in mitotic spindle salt of a natural alkaloid with antimitotic and antineoplastic activities	127
Iodoquinol	2	Antiprotozoal agent used as an amebicide drug	Unknown	128
Miltefosine	10	Antiprotozoal, bactericidal and antifungal agent	Unknown	129