FIG 8.

Galectin-8 and TAX1BP1 recognize and target Mtb to selective autophagy in macrophages. Schematic representation of how Mtb is detected by macrophages. Galectin-8 binds to cytosolically exposed glycans in the lumen of damaged Mtb-containing phagosomes. TAX1BP1 is recruited to these damaged phagosomes via its interaction with galectin-8, as well as through its interaction with ubiquitinated substrates. Deletion of galectin-8 results in less targeting of Mtb and increased Mtb survival/replication, while overexpression of galectin-8 leads to increased targeting and less Mtb replication.