Table 1.

Demographics of each risk group follow up and BRRM.

	Grp 1 v high 40–49%	Grp 2 high 30–39%	Grp 3 high moderate 25–29%	High risk mutation known in family at entry	Grp1-3a post fam BRCA result	Total	BRCA1/2 carriers from Individual test	untested high risk gene	Negative for BRCA in family	non BRCA carrier
Total	1261	3561	1783	590	407	7195	479b	191	289+	16
age range at entry+ (years)	16.0–70.1	16.9–72.0	16.7–70.8	18.3–77.4	22.2–78.2	16–77.4	18.6–75.7+	19.7–69	18.8–68.3+	30.3–48.6+
Median	38.0	38.9	40.2	36.1	42.4	38.9	38.4	37.7	42.1	35.8
age range at censor (years)	16.0–85.2	17.8–89.2	18.9–98.8	24.3–88.0	27.6–91.2	16.0–98.8	24.3–88.0	25.2–91.2	25.0–81.9	35.0–72.1
Median	52.4	51.6	53.0	44.6	54.3	51.6	44.0	50.41	53.3	47.7
Parous	915	2455	1203	390	331	4963	355	125	218	10
% parous	72.56%	68.94%	67.47%	66.10%	81.33%	68.98%	74.11%	65.45%	75.43%	66.67%
non malignant biopsy	106	290	139	44	51	579	40	22	29	3
%	8.41%	8.14%	7.80%	7.46%	12.53%	8.05%	8.35%	11.52%	10.03%	20.00%
Sister/mother death BC	310	666	358	83	126	1417	108	37	55	3
%	24.58%	18.70%	20.08%	14.07%	30.96%	19.69%	22.55%	19.37%	19.03%	20.00%
BRRM	87	127	36	146	55	451	193	2	1	4
%	6.90%	3.57%	2.02%	24.75%	13.51%	6.27%	40.29%	1.05%	0.34%	26.67%
median to BRRM years	2.8	3.5	4.3	1.7	1.9		1.5	2.98
years fu	15017.09	40595.32	22243.15	4400.15	4530.445	86786.16	2866.48	2404.97	2977.84	177.62
BC in total population	76	165	76	33	33	383	42	4	4	1
BC rate per 1000/year	5.06	4.06	3.42	7.50	7.73	4.41	14.65	1.66	1.34	5.63
							b82 censored before test		+20 censored before test

^aNumbers counted in this group are already counted in Groups 1–3 but breast cancers and BRRM occurred after censoring for identification of a family PV, group excludes those who were censored before PV (55 BC, 29 BRRM, 2 died, 5 moved area); BC = breast cancer.

^bor from genetic test in later columns.