Table 3.

Multivariate cause-specific Cox regression and Fine and Gray regression model: All variables adjusted for other factors in the model.

		Cause specific - RRM	Cause specific - other	SHR - RRM	SHR - other
Risk group	Group 3 25–29%	Ref		Ref
	Group 2 30–39%	1.78 (1.22–2.58)	1.31 (1.01–1.70)	1.76 (1.21–2.56)	1.31 (1.01–1.70)
	Group 1 ≥ 40%	3.22 (2.17–4.77)	1.70 (1.25–2.29)	3.17 (2.14–4.71)	1.64 (1.21–2.20)
	BRCA1/2	36.46 (25.18–52.79)	5.71 (3.97–8.20)	34.39 (23.68–49.93)	3.84 (2.63–5.60)
	High risk non-BRCA	1.57 (0.69–3.54)	0.54 (0.20–1.48)	1.57 (0.70–3.55)	0.54 (0.20–1.50)
Mother died BC	No	Ref		Ref
	Yes	1.86 (1.49–2.31)	1.23 (0.96–1.55)	1.86 (1.51–2.30)	1.17 (0.93–1.48)
Sister died BC	No	Ref		Ref
	Yes	2.36 (1.66–3.35)	1.04 (0.73–1.50)	2.33 (1.62–3.33)	0.99 (0.69–1.42)
Age entry	<30	Ref	Ref		Ref
	30–39	0.80 (0.61–1.04)	1.90 (1.24–2.92)	0.78 (0.60–1.08)	1.94 (1.27–2.95)
	40–49	0.48 (0.35–0.65)	2.47 (1.61–3.80)	0.46 (0.34–0.63)	2.63 (1.72–4.03)
	50+	0.26 (0.17–0.41)	3.45 (2.18–5.46)	0.26 (0.16–0.40)	3.78 (2.40–5.96)
Biopsy	No	Ref		Ref
	Yes	1.36 (1.02–1.82)	0.12 (0.06–0.26)	1.42 (1.06–1.91)	0.12 (0.06–0.26)
Parity	Nulliparous	Ref		Ref
	Parous	1.43 (1.13–1.81)	1.09 (0.85–1.38)	1.44 (1.13–1.82)	1.07 (0.84–1.36)
Era	<1994	Ref		Ref
	1994–2003	1.03 (0.69–1.53)	0.49 (0.38–0.64)	1.01 (0.68–1.49)	0.48 (0.37–0.62)
	2003-04/2013	1.02 (0.67–1.55)	0.34 (0.25–0.46)	1.00 (0.66–1.50)	0.31 (0.23–0.43)
	> May 2013	1.68 (1.05–2.69)	0.17 (0.09–0.33)	1.66 (1.06–2.61)	0.14 (0.07–0.25)

(n.b. sister BC death and mother BC deaths entered rather than mother or sister vs no FDR BC death – as this excludes those that have a mother or sister with BC death due to missing values). RRM – risk reducing mastectomy, HR – hazard ratio, SHR – subhazard ratio, CI – confidence interval.