Table 1:
Patient Characteristics
| Group 1: Immune Tolerant | Sex | Age | ALT IU/L | HBV Geno-type | HBeAg/anti-HBe | HBV DNA log IU/ ml | HBsAg titer log IU/ml | Fibrosis Stage (/6) | HAI (/18) | Peripheral T cell analysis* | IHC & Image analysis* |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Pt. 1 | F | 15 | 36 | E | +/− | 8.69 | 5.22 | 2 | 3 | Yes | Yes |
| Pt. 2 | M | 17 | 29 | C | +/− | 9.17 | 4.59 | 1 | 2 | Yes | Yes |
| Pt. 3 | F | 18 | 18 | B | +/− | 8.42 | 4.68 | 0 | 2 | Yes | Yes |
| Pt. 4 | M | 18 | 38 | D | +/− | 9.71 | 5.16 | 2 | 2 | Yes | Yes |
| Pt. 5 | M | 22 | 40 | E | +/− | 8.66 | 4.36 | 3 | 3 | Yes | Yes |
| Pt. 6 | F | 24 | 38 | C | +/− | 8.58 | 4.52 | 1 | 2 | No | No |
| Pt. 7 | F | 28 | 30 | E | +/− | 7.60 | 4.57 | 1 | 4 | No | Yes |
| Pt. 8 | F | 30 | 32 | C | +/− | 8.51 | 4.89 | 1 | 3 | Yes | Yes |
| Pt. 9 | F | 39 | 31 | B | +/− | 8.52 | 4.55 | 1 | 2 | No | Yes |
| Group 2: HBeAg(+) IA | |||||||||||
| Pt. 10 | M | 14 | 70 | D | +/− | 8.80 | 4.17 | 2 | 3 | Yes | Yes |
| Pt. 11 | M | 14 | 99 | A | +/− | 8.19 | 4.11 | 3 | 4 | No | No |
| Pt. 12 | F | 16 | 63 | D | +/− | 7.06 | 2.67 | 1 | 3 | No | No |
| Pt. 13 | F | 17 | 127 | D | +/− | 7.98 | 3.02 | 3 | 5 | Yes | Yes |
| Pt. 14 | M | 19 | 89 | C | +/− | 8.49 8.32 |
4.82 | 3 | 3 | Yes | Yes |
| Pt. 15 | F | 23 | 172 | A | +/− | 8.32 | 4.19 | 2 | 7 | No | No |
| Pt. 16 | M | 25 | 77 | B | +/− | 8.36 | 4.76 | 1 | 2 | Yes | Yes |
| Pt. 17 | M | 25 | 59 | D | +/− | 8.19 | 5.13 | 1 | 3 | No | No |
| Pt. 18 | F | 28 | 161 | C | +/− | 7.09 | 2.29 | 1 | 6 | Yes | Yes |
| Pt. 19 | F | 29 | 68 | B | +/− | 8.59 | 5.09 | 1 | 4 | No | No |
|
Group 3: HBeAg(−)
IA |
|||||||||||
| Pt. 20 | M | 23 | 113 | D | −/+ | 3.64 | 4.09 | 2 | 2 | Yes | Yes |
| Pt. 21 | F | 25 | 29 | E | −/+ | 4.19 | 3.73 | 1 | 2 | Yes | Yes |
| Pt. 22 | M | 26 | 55 | D | −/+ | 2.62 | 4.15 | 1 | 2 | No | No |
| Pt. 23 | M | 26 | 118 | D | −/+ | 3.94 | 5.09 | 0 | 1 | Yes | Yes |
| Pt. 24 | M | 26 | 110 | C | −/+ | 6.31 | 3.82 | 4 | 5 | No | Yes |
| Pt. 25 | F | 27 | 23 | D | −/+ | 6.70 | 4.03 | 1 | 2 | Yes | Yes |
| Pt. 26 | M | 29 | 81 | C | −/+ | 8.22 | 4.49 | 2 | 5 | No | Yes |
Group 1: HBeAg positive/HBeAb negative; ALT ≤40 (median 32 IU/L); HBV DNA ≥ 7.50 (median 8.58 log IU/ml)
Group 2: HBeAg positive/HBeAb negative; ALT >40 (median 83 IU/L); HBV DNA >7.00 (median 8.26 log IU/ml)
Group 3: HBeAg negative/HBeAb positive; ALT ≥ 40 with HBV DNA at any level, or if ALT ≤40 with HBV DNA >3.3 (median ALT 81 IU/L; median HBV DNA 4.19 log IU/ml)
*
Columns indicating whether or not peripheral T cell analyses and IHC were carried out. T cell results are presented in Figure 2 and IHC in Figure 3. All samples were analyzed for HBV DNA integration and clonal hepatocyte expansion.
HAI, histological activity index